Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 75691..75990 Replicon chromosome
Accession NZ_CP077854
Organism Staphylococcus aureus strain N4

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU508_RS00440 Protein ID WP_011447039.1
Coordinates 75814..75990 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 75691..75746 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU508_RS00400 71021..71281 + 261 WP_001791826.1 hypothetical protein -
KU508_RS00405 71334..71684 - 351 WP_000702263.1 complement inhibitor SCIN-A -
KU508_RS00410 72370..72819 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU508_RS00415 72914..73249 - 336 Protein_82 SH3 domain-containing protein -
KU508_RS00420 73899..74390 - 492 WP_000919350.1 staphylokinase -
KU508_RS00425 74581..75336 - 756 WP_000861038.1 CHAP domain-containing protein -
KU508_RS00430 75348..75602 - 255 WP_000611512.1 phage holin -
KU508_RS00435 75654..75761 + 108 WP_001791821.1 hypothetical protein -
- 75683..75822 + 140 NuclAT_0 - -
- 75683..75822 + 140 NuclAT_0 - -
- 75683..75822 + 140 NuclAT_0 - -
- 75683..75822 + 140 NuclAT_0 - -
- 75691..75746 + 56 - - Antitoxin
KU508_RS00440 75814..75990 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
KU508_RS00445 76099..76872 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU508_RS00450 77293..77667 - 375 WP_000340977.1 hypothetical protein -
KU508_RS00455 77723..78010 - 288 WP_001040259.1 hypothetical protein -
KU508_RS00460 78057..78209 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / chp / sak / sea / hlb / groEL 66323..126191 59868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208115 WP_011447039.1 NZ_CP077854:c75990-75814 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208115 NZ_CP103570:c3624874-3624476 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 56 bp

>AT208115 NZ_CP077854:75691-75746 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References