225608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2098933..2099232 Replicon chromosome
Accession NZ_CP087593
Organism Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag LO764_RS10615 Protein ID WP_011447039.1
Coordinates 2099056..2099232 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2098933..2098988 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO764_RS10575 2094264..2094524 + 261 WP_001791826.1 hypothetical protein -
LO764_RS10580 2094577..2094927 - 351 WP_000702263.1 complement inhibitor SCIN-A -
LO764_RS10585 2095612..2096061 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
LO764_RS10590 2096156..2096491 - 336 Protein_2052 SH3 domain-containing protein -
LO764_RS10595 2097141..2097632 - 492 WP_000919350.1 staphylokinase -
LO764_RS10600 2097823..2098578 - 756 WP_000861038.1 CHAP domain-containing protein -
LO764_RS10605 2098590..2098844 - 255 WP_000611512.1 phage holin -
LO764_RS10610 2098896..2099003 + 108 WP_001791821.1 hypothetical protein -
- 2098925..2099064 + 140 NuclAT_0 - -
- 2098925..2099064 + 140 NuclAT_0 - -
- 2098925..2099064 + 140 NuclAT_0 - -
- 2098925..2099064 + 140 NuclAT_0 - -
- 2098933..2098988 + 56 - - Antitoxin
LO764_RS10615 2099056..2099232 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
LO764_RS10620 2099341..2100114 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
LO764_RS10625 2100535..2100909 - 375 WP_000340977.1 hypothetical protein -
LO764_RS10630 2100965..2101252 - 288 WP_001040259.1 hypothetical protein -
LO764_RS10635 2101299..2101451 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2094577..2154552 59975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T225608 WP_011447039.1 NZ_CP087593:c2099232-2099056 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T225608 NZ_CP121208:723565-723795 [Arcanobacterium canis]
ATGAGCTTGCTCAAGGGCGTCATTCAACTCATCGTCCAAAACGATAAAGAATCGTTGGTGGAGCTGCGTCGTCGGCACCG
GATGCATGAGCTGAAGGGGAACTGGGCCGGAGCCAAGGAGTGCCATGTGGCCAACTTGGGCGACTGGTTGTGCGTCTGGC
AGGTCTCCGACGGTCTTGCAATCTTCCTGCGCACCGGCACCCGTGACGAAATATTCCGGTCAAACCCCTAG

Antitoxin


Download         Length: 56 bp

>AT225608 NZ_CP087593:2098933-2098988 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References