153116

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2575483..2575906 Replicon chromosome
Accession NZ_CP050691
Organism Staphylococcus aureus strain PMB196-1

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag HCU71_RS12585 Protein ID WP_001065091.1
Coordinates 2575655..2575906 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag HCU71_RS12580 Protein ID WP_000028422.1
Coordinates 2575483..2575665 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU71_RS12535 2570870..2572531 - 1662 WP_000625088.1 terminase large subunit -
HCU71_RS12540 2572528..2572872 - 345 WP_000402904.1 hypothetical protein -
HCU71_RS12545 2572929..2573300 - 372 WP_167780480.1 HNH endonuclease -
HCU71_RS12550 2573532..2573948 - 417 WP_000590122.1 hypothetical protein -
HCU71_RS12555 2573976..2574176 - 201 WP_000265043.1 DUF1514 family protein -
HCU71_RS12560 2574176..2574325 - 150 WP_000595265.1 transcriptional activator RinB -
HCU71_RS12565 2574322..2574708 - 387 WP_000592207.1 hypothetical protein -
HCU71_RS12570 2574705..2574911 - 207 WP_000195803.1 DUF1381 domain-containing protein -
HCU71_RS12575 2574948..2575490 - 543 WP_000185659.1 dUTP pyrophosphatase -
HCU71_RS12580 2575483..2575665 - 183 WP_000028422.1 hypothetical protein Antitoxin
HCU71_RS12585 2575655..2575906 - 252 WP_001065091.1 DUF1024 family protein Toxin
HCU71_RS12590 2575899..2576066 - 168 WP_001624242.1 hypothetical protein -
HCU71_RS12595 2576078..2576320 - 243 WP_000131366.1 hypothetical protein -
HCU71_RS12600 2576324..2576692 - 369 WP_000101274.1 hypothetical protein -
HCU71_RS12605 2576705..2577014 - 310 Protein_2436 RusA family crossover junction endodeoxyribonuclease -
HCU71_RS12610 2577023..2577241 - 219 WP_000338531.1 hypothetical protein -
HCU71_RS12615 2577248..2578132 - 885 WP_000148316.1 DnaD domain protein -
HCU71_RS12620 2578162..2578632 - 471 WP_000934764.1 single-stranded DNA-binding protein -
HCU71_RS12625 2578633..2579250 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
HCU71_RS12630 2579331..2580251 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2547816..2599647 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T153116 WP_001065091.1 NZ_CP050691:c2575906-2575655 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T153116 NZ_CP066759:227373-227480 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT153116 WP_000028422.1 NZ_CP050691:c2575665-2575483 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT153116 NZ_CP066759:c227325-227259 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References