208199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2679202..2679540 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU543_RS13260 Protein ID WP_011447039.1
Coordinates 2679202..2679378 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2679366..2679540 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS13240 2676983..2677135 + 153 WP_001153681.1 hypothetical protein -
KU543_RS13245 2677182..2677469 + 288 WP_001040259.1 hypothetical protein -
KU543_RS13250 2677525..2677899 + 375 WP_000340977.1 hypothetical protein -
KU543_RS13255 2678320..2679093 + 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU543_RS13260 2679202..2679378 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 2679366..2679540 - 175 - - Antitoxin
KU543_RS13270 2679590..2679844 + 255 WP_000611512.1 phage holin -
KU543_RS13275 2679856..2680611 + 756 WP_000861038.1 CHAP domain-containing protein -
KU543_RS13280 2680802..2681293 + 492 WP_000919350.1 staphylokinase -
KU543_RS13285 2681943..2682278 + 336 Protein_2577 SH3 domain-containing protein -
KU543_RS13290 2682373..2682822 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU543_RS13295 2683508..2683858 + 351 WP_000702263.1 complement inhibitor SCIN-A -
KU543_RS13300 2683911..2684171 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sea / sak / chp / scn 2636293..2683858 47565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208199 WP_011447039.1 NZ_CP077858:2679202-2679378 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208199 NZ_CP103592:186695-186802 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 175 bp

>AT208199 NZ_CP077858:c2679540-2679366 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References