Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2679700..2680038 Replicon chromosome
Accession NZ_CP077853
Organism Staphylococcus aureus strain N5

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU499_RS13265 Protein ID WP_011447039.1
Coordinates 2679700..2679876 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2679864..2680038 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU499_RS13245 2677481..2677633 + 153 WP_001153681.1 hypothetical protein -
KU499_RS13250 2677680..2677967 + 288 WP_001040259.1 hypothetical protein -
KU499_RS13255 2678023..2678397 + 375 WP_000340977.1 hypothetical protein -
KU499_RS13260 2678818..2679591 + 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU499_RS13265 2679700..2679876 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 2679864..2680038 - 175 - - Antitoxin
KU499_RS13275 2680088..2680342 + 255 WP_000611512.1 phage holin -
KU499_RS13280 2680354..2681109 + 756 WP_000861038.1 CHAP domain-containing protein -
KU499_RS13285 2681300..2681791 + 492 WP_000919350.1 staphylokinase -
KU499_RS13290 2682441..2682776 + 336 Protein_2578 SH3 domain-containing protein -
KU499_RS13295 2682871..2683320 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU499_RS13300 2684006..2684356 + 351 WP_000702263.1 complement inhibitor SCIN-A -
KU499_RS13305 2684409..2684669 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sea / sak / chp / scn 2636791..2684356 47565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208111 WP_011447039.1 NZ_CP077853:2679700-2679876 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208111 NZ_CP103570:c2433329-2433153 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 175 bp

>AT208111 NZ_CP077853:c2680038-2679864 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References