Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2010793..2011216 Replicon chromosome
Accession NZ_CP094857
Organism Staphylococcus aureus strain ATCC 29213

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag MTX75_RS09925 Protein ID WP_001065091.1
Coordinates 2010965..2011216 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag MTX75_RS09920 Protein ID WP_000028422.1
Coordinates 2010793..2010975 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX75_RS09875 (2006179) 2006179..2007840 - 1662 WP_000625088.1 terminase large subunit -
MTX75_RS09880 (2007837) 2007837..2008181 - 345 WP_000402904.1 hypothetical protein -
MTX75_RS09885 (2008311) 2008311..2008610 - 300 WP_000988336.1 HNH endonuclease -
MTX75_RS09890 (2008842) 2008842..2009258 - 417 WP_000590122.1 hypothetical protein -
MTX75_RS09895 (2009286) 2009286..2009486 - 201 WP_000265043.1 DUF1514 family protein -
MTX75_RS09900 (2009486) 2009486..2009635 - 150 WP_000595265.1 transcriptional activator RinB -
MTX75_RS09905 (2009632) 2009632..2010018 - 387 WP_000592207.1 hypothetical protein -
MTX75_RS09910 (2010015) 2010015..2010221 - 207 WP_000195803.1 DUF1381 domain-containing protein -
MTX75_RS09915 (2010258) 2010258..2010800 - 543 WP_000185659.1 dUTP pyrophosphatase -
MTX75_RS09920 (2010793) 2010793..2010975 - 183 WP_000028422.1 hypothetical protein Antitoxin
MTX75_RS09925 (2010965) 2010965..2011216 - 252 WP_001065091.1 DUF1024 family protein Toxin
MTX75_RS09930 (2011209) 2011209..2011376 - 168 WP_001624242.1 hypothetical protein -
MTX75_RS09935 (2011388) 2011388..2011630 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
MTX75_RS09940 (2011634) 2011634..2012002 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
MTX75_RS09945 (2012015) 2012015..2012324 - 310 Protein_1921 RusA family crossover junction endodeoxyribonuclease -
MTX75_RS09950 (2012333) 2012333..2012551 - 219 WP_000338531.1 hypothetical protein -
MTX75_RS09955 (2012558) 2012558..2013442 - 885 WP_000148316.1 DnaD domain protein -
MTX75_RS09960 (2013472) 2013472..2013942 - 471 WP_000934764.1 single-stranded DNA-binding protein -
MTX75_RS09965 (2013943) 2013943..2014560 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
MTX75_RS09970 (2014641) 2014641..2015561 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 1983126..2034957 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T240701 WP_001065091.1 NZ_CP094857:c2011216-2010965 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T240701 NZ_LT615377:c3165057-3164761 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT240701 WP_000028422.1 NZ_CP094857:c2010975-2010793 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT240701 NZ_LT615377:c3164759-3164364 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References