Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2093784..2094083 Replicon chromosome
Accession NZ_LT598688
Organism Staphylococcus aureus isolate Sa_Newman_UoM

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag BN8422_RS15440 Protein ID WP_011447039.1
Coordinates 2093907..2094083 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2093784..2093839 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN8422_RS10810 2089115..2089375 + 261 WP_001791826.1 hypothetical protein -
BN8422_RS10815 2089428..2089778 - 351 WP_000702263.1 complement inhibitor SCIN-A -
BN8422_RS10820 2090463..2090912 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
BN8422_RS15730 2091007..2091342 - 336 Protein_2049 SH3 domain-containing protein -
BN8422_RS10830 2091992..2092483 - 492 WP_000919350.1 staphylokinase -
BN8422_RS10835 2092674..2093429 - 756 WP_000861038.1 CHAP domain-containing protein -
BN8422_RS10840 2093441..2093695 - 255 WP_000611512.1 phage holin -
BN8422_RS10845 2093747..2093854 + 108 WP_001791821.1 hypothetical protein -
- 2093776..2093915 + 140 NuclAT_0 - -
- 2093776..2093915 + 140 NuclAT_0 - -
- 2093776..2093915 + 140 NuclAT_0 - -
- 2093776..2093915 + 140 NuclAT_0 - -
- 2093784..2093839 + 56 - - Antitoxin
BN8422_RS15440 2093907..2094083 - 177 WP_011447039.1 putative holin-like toxin Toxin
BN8422_RS10850 2094192..2094965 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
BN8422_RS10855 2095386..2095760 - 375 WP_000340977.1 hypothetical protein -
BN8422_RS10860 2095816..2096103 - 288 WP_001040259.1 hypothetical protein -
BN8422_RS10865 2096150..2096302 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2089428..2146378 56950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T293247 WP_011447039.1 NZ_LT598688:c2094083-2093907 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT293247 NZ_LT598688:2093784-2093839 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References