Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1987440..1987747 Replicon chromosome
Accession NZ_CP078521
Organism Staphylococcus aureus strain ATCC 29213

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KWH15_RS09770 Protein ID WP_011447039.1
Coordinates 1987571..1987747 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1987440..1987579 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWH15_RS09730 (1982778) 1982778..1983038 + 261 WP_001791826.1 hypothetical protein -
KWH15_RS09735 (1983091) 1983091..1983441 - 351 WP_000702263.1 complement inhibitor SCIN-A -
KWH15_RS09740 (1984127) 1984127..1984576 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KWH15_RS09745 (1984671) 1984671..1985006 - 336 Protein_1884 SH3 domain-containing protein -
KWH15_RS09750 (1985656) 1985656..1986147 - 492 WP_000919350.1 staphylokinase -
KWH15_RS09755 (1986338) 1986338..1987093 - 756 WP_000861038.1 CHAP domain-containing protein -
KWH15_RS09760 (1987105) 1987105..1987359 - 255 WP_000611512.1 phage holin -
KWH15_RS09765 (1987411) 1987411..1987518 + 108 WP_001791821.1 hypothetical protein -
- (1987440) 1987440..1987579 + 140 NuclAT_0 - Antitoxin
- (1987440) 1987440..1987579 + 140 NuclAT_0 - Antitoxin
- (1987440) 1987440..1987579 + 140 NuclAT_0 - Antitoxin
- (1987440) 1987440..1987579 + 140 NuclAT_0 - Antitoxin
KWH15_RS09770 (1987571) 1987571..1987747 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
KWH15_RS09775 (1987856) 1987856..1988629 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
KWH15_RS09780 (1989050) 1989050..1989424 - 375 WP_000340977.1 hypothetical protein -
KWH15_RS09785 (1989480) 1989480..1989767 - 288 WP_001040259.1 hypothetical protein -
KWH15_RS09790 (1989814) 1989814..1989966 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 1983091..2034922 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T209202 WP_011447039.1 NZ_CP078521:c1987747-1987571 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T209202 NZ_CP103960:c960832-960587 [Brucella sp. 2594]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTCCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 140 bp

>AT209202 NZ_CP078521:1987440-1987579 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References