Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2122244..2122667 Replicon chromosome
Accession NZ_CP087593
Organism Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag LO764_RS10760 Protein ID WP_001065091.1
Coordinates 2122416..2122667 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag LO764_RS10755 Protein ID WP_000028422.1
Coordinates 2122244..2122426 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO764_RS10710 (2117630) 2117630..2119291 - 1662 WP_000625088.1 terminase large subunit -
LO764_RS10715 (2119288) 2119288..2119632 - 345 WP_000402904.1 hypothetical protein -
LO764_RS10720 (2119762) 2119762..2120061 - 300 WP_000988336.1 HNH endonuclease -
LO764_RS10725 (2120293) 2120293..2120709 - 417 WP_000590122.1 hypothetical protein -
LO764_RS10730 (2120737) 2120737..2120937 - 201 WP_000265043.1 DUF1514 family protein -
LO764_RS10735 (2120937) 2120937..2121086 - 150 WP_000595265.1 transcriptional activator RinB -
LO764_RS10740 (2121083) 2121083..2121469 - 387 WP_000592210.1 hypothetical protein -
LO764_RS10745 (2121466) 2121466..2121672 - 207 WP_000195803.1 DUF1381 domain-containing protein -
LO764_RS10750 (2121709) 2121709..2122251 - 543 WP_000185659.1 dUTP pyrophosphatase -
LO764_RS10755 (2122244) 2122244..2122426 - 183 WP_000028422.1 hypothetical protein Antitoxin
LO764_RS10760 (2122416) 2122416..2122667 - 252 WP_001065091.1 DUF1024 family protein Toxin
LO764_RS10765 (2122660) 2122660..2122827 - 168 WP_001624242.1 hypothetical protein -
LO764_RS10770 (2122839) 2122839..2123081 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
LO764_RS10775 (2123085) 2123085..2123453 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
LO764_RS10780 (2123466) 2123466..2123870 - 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
LO764_RS10785 (2123879) 2123879..2124097 - 219 WP_000338530.1 hypothetical protein -
LO764_RS10790 (2124104) 2124104..2124988 - 885 WP_000148316.1 DnaD domain protein -
LO764_RS10795 (2125018) 2125018..2125488 - 471 WP_000934764.1 single-stranded DNA-binding protein -
LO764_RS10800 (2125489) 2125489..2126106 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
LO764_RS10805 (2126187) 2126187..2127107 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2094577..2154552 59975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T225612 WP_001065091.1 NZ_CP087593:c2122667-2122416 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T225612 NZ_CP121222:c14870-14565 [Shigella flexneri 2a]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT225612 WP_000028422.1 NZ_CP087593:c2122426-2122244 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT225612 NZ_CP121222:c15090-14872 [Shigella flexneri 2a]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References