Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2586111..2586410 Replicon chromosome
Accession NZ_CP079715
Organism Staphylococcus aureus strain V8

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KX797_RS12980 Protein ID WP_011447039.1
Coordinates 2586234..2586410 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2586111..2586166 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX797_RS12940 2581442..2581702 + 261 WP_001791826.1 hypothetical protein -
KX797_RS12945 2581755..2582105 - 351 WP_000702263.1 complement inhibitor SCIN-A -
KX797_RS12950 2582790..2583239 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KX797_RS12955 2583334..2583669 - 336 Protein_2521 SH3 domain-containing protein -
KX797_RS12960 2584319..2584810 - 492 WP_000919350.1 staphylokinase -
KX797_RS12965 2585001..2585756 - 756 WP_000861038.1 CHAP domain-containing protein -
KX797_RS12970 2585768..2586022 - 255 WP_000611512.1 phage holin -
KX797_RS12975 2586074..2586181 + 108 WP_001791821.1 hypothetical protein -
- 2586103..2586242 + 140 NuclAT_0 - -
- 2586103..2586242 + 140 NuclAT_0 - -
- 2586103..2586242 + 140 NuclAT_0 - -
- 2586103..2586242 + 140 NuclAT_0 - -
- 2586111..2586166 + 56 - - Antitoxin
KX797_RS12980 2586234..2586410 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
KX797_RS12985 2586519..2587292 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
KX797_RS12990 2587713..2588087 - 375 WP_000340977.1 hypothetical protein -
KX797_RS12995 2588143..2588430 - 288 WP_001040259.1 hypothetical protein -
KX797_RS13000 2588477..2588629 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2581755..2638705 56950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T209767 WP_011447039.1 NZ_CP079715:c2586410-2586234 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T209767 NZ_CP104302:c2372367-2371963 [Mycolicibacterium brumae]
ATGATCTACCTCGACACCTCCGCTCTGGTGAAACTGCTCGTCACCGAGGACGAGACGCCCGCCTTGAGAAGGTGGCTTTC
GGAACAGACCTCAGGCGGGGTGTTCGCAGCCACCAGCACGCTGGGTCGGATCGAGCTGATGAGGGCCGCCGCTCGATATT
CCGAACCGGGGCTCGCTGACCGCGCGCGGTTCCTGCTCGACGGGATGGACCTGCTGCCGCTCACTGAATCTGTGCTGACC
CTCGCGGAAACAATCGGCCCGCCTTCACTGCGATCCCTCGACGCAATCCACCTGGCGGCGGCCGCCCACGTCCGCGATGA
ACTGACGGCGTTCGTGACGTATGACCGGCGACTGCTCGACGGCTGCTGTGACGTGGGGCTTGCCGTCGTGTCGCCCGGCG
CGTAG

Antitoxin


Download         Length: 56 bp

>AT209767 NZ_CP079715:2586111-2586166 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References