Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 749258..749681 Replicon chromosome
Accession NZ_CP064389
Organism Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag IUJ40_RS03810 Protein ID WP_001065091.1
Coordinates 749258..749509 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag IUJ40_RS03815 Protein ID WP_000028422.1
Coordinates 749499..749681 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ40_RS03765 (744924) 744924..745844 + 921 WP_000138472.1 recombinase RecT -
IUJ40_RS03770 (745925) 745925..746542 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
IUJ40_RS03775 (746543) 746543..747013 + 471 WP_000934764.1 single-stranded DNA-binding protein -
IUJ40_RS03780 (747043) 747043..747916 + 874 Protein_741 DnaD domain protein -
IUJ40_RS03785 (747923) 747923..748141 + 219 WP_000338531.1 hypothetical protein -
IUJ40_RS03790 (748150) 748150..748459 + 310 Protein_743 RusA family crossover junction endodeoxyribonuclease -
IUJ40_RS03795 (748472) 748472..748840 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
IUJ40_RS03800 (748844) 748844..749086 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
IUJ40_RS03805 (749101) 749101..749265 + 165 WP_000990744.1 hypothetical protein -
IUJ40_RS03810 (749258) 749258..749509 + 252 WP_001065091.1 DUF1024 family protein Toxin
IUJ40_RS03815 (749499) 749499..749681 + 183 WP_000028422.1 hypothetical protein Antitoxin
IUJ40_RS03820 (749674) 749674..750216 + 543 WP_000185659.1 dUTP pyrophosphatase -
IUJ40_RS03825 (750253) 750253..750459 + 207 WP_000195803.1 DUF1381 domain-containing protein -
IUJ40_RS03830 (750456) 750456..750842 + 387 WP_000592207.1 hypothetical protein -
IUJ40_RS03835 (750839) 750839..750988 + 150 WP_000595265.1 transcriptional activator RinB -
IUJ40_RS03840 (750988) 750988..751188 + 201 WP_000265043.1 DUF1514 family protein -
IUJ40_RS03845 (751216) 751216..751632 + 417 WP_000590122.1 hypothetical protein -
IUJ40_RS03850 (751864) 751864..752163 + 300 WP_000988336.1 HNH endonuclease -
IUJ40_RS03855 (752293) 752293..752637 + 345 WP_000402904.1 hypothetical protein -
IUJ40_RS03860 (752634) 752634..754295 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / sea / sak / chp / scn 716150..778681 62531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T181127 WP_001065091.1 NZ_CP064389:749258-749509 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T181127 NZ_CP085805:3754618-3754836 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT181127 WP_000028422.1 NZ_CP064389:749499-749681 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT181127 NZ_CP085805:3754216-3754590 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References