Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2010758..2011181 Replicon chromosome
Accession NZ_CP078521
Organism Staphylococcus aureus strain ATCC 29213

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KWH15_RS09920 Protein ID WP_001065091.1
Coordinates 2010930..2011181 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KWH15_RS09915 Protein ID WP_000028422.1
Coordinates 2010758..2010940 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWH15_RS09870 (2006144) 2006144..2007805 - 1662 WP_000625088.1 terminase large subunit -
KWH15_RS09875 (2007802) 2007802..2008146 - 345 WP_000402904.1 hypothetical protein -
KWH15_RS09880 (2008276) 2008276..2008575 - 300 WP_000988336.1 HNH endonuclease -
KWH15_RS09885 (2008807) 2008807..2009223 - 417 WP_000590122.1 hypothetical protein -
KWH15_RS09890 (2009251) 2009251..2009451 - 201 WP_000265043.1 DUF1514 family protein -
KWH15_RS09895 (2009451) 2009451..2009600 - 150 WP_000595265.1 transcriptional activator RinB -
KWH15_RS09900 (2009597) 2009597..2009983 - 387 WP_000592207.1 hypothetical protein -
KWH15_RS09905 (2009980) 2009980..2010186 - 207 WP_000195803.1 DUF1381 domain-containing protein -
KWH15_RS09910 (2010223) 2010223..2010765 - 543 WP_000185659.1 dUTP pyrophosphatase -
KWH15_RS09915 (2010758) 2010758..2010940 - 183 WP_000028422.1 hypothetical protein Antitoxin
KWH15_RS09920 (2010930) 2010930..2011181 - 252 WP_001065091.1 DUF1024 family protein Toxin
KWH15_RS09925 (2011174) 2011174..2011341 - 168 WP_001624242.1 hypothetical protein -
KWH15_RS09930 (2011353) 2011353..2011595 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KWH15_RS09935 (2011599) 2011599..2011967 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KWH15_RS09940 (2011980) 2011980..2012289 - 310 Protein_1923 RusA family crossover junction endodeoxyribonuclease -
KWH15_RS09945 (2012298) 2012298..2012516 - 219 WP_000338531.1 hypothetical protein -
KWH15_RS09950 (2012523) 2012523..2013407 - 885 WP_000148316.1 DnaD domain protein -
KWH15_RS09955 (2013437) 2013437..2013907 - 471 WP_000934764.1 single-stranded DNA-binding protein -
KWH15_RS09960 (2013908) 2013908..2014525 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
KWH15_RS09965 (2014606) 2014606..2015526 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 1983091..2034922 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T209205 WP_001065091.1 NZ_CP078521:c2011181-2010930 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T209205 NZ_CP103964:1006645-1006800 [Staphylococcus hyicus]
ATGTCTGAAGAAAAACATATCGAACATGAAAATGAGATGGTAGATAATTTCGATGATCTTGTGCAATTAGGCAAAGAAAT
GGAACAGATTTCTGAAACAAATGATCAAGACAAATTGAACCAATCACATGACTCTGAGGGACGTTCAAATCAATAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT209205 WP_000028422.1 NZ_CP078521:c2010940-2010758 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT209205 NZ_CP103964:1006027-1006626 [Staphylococcus hyicus]
ATGGCAATGAACTTTAAAGTTTTTAAAGACAAAGATACTGCAGCGATTTATGCGGCGGATATCATTAGAAAACAATTCAA
TAATAATCCAACAACGATCGCAGGGTTTCATTTAAATGAGGAAGCGGCACCAGTGCTTGATTATTTAAAGCGTAATGTTG
ATGACCATGCGGTTGATTTTAGTCAAATTCACATTTTAGATTACGATAAACAAACATCATACTTTAAAGCATTAGGTGTA
CCAGAAAAACAAATTCATGAAATTCCAGAAGAAGATGAAGTTGAAAAATTTATTGAACGTAAAGCGAAGACGAAAGACAA
TAAAGGCAAACTCACATTGCAAGTTGTTTCAATCAATAACAAAGGTGAATTTGGTATTCCTGTTACGAATGGTTTAAAGC
CTGCACGTGAAATTTTTGTTGTTGTGACAGGAAGTGAAAAAGCGGATGTCATTAAAAAATTATATGAAGACAATGGTAAT
ACAAGCTTTATTCCTTCAAGTTTAAAAGCTCACCGTATGGTCAATGTCATTCTTGATGAAGCTGCTGCGCAAGGGTTACC
TGATGATGTAAGAGCGTACTTCACTTCACTTTATGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References