170204

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2433037..2433460 Replicon chromosome
Accession NZ_CP060278
Organism Staphylococcus aureus strain KZN

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag H7684_RS11910 Protein ID WP_001065091.1
Coordinates 2433209..2433460 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag H7684_RS11905 Protein ID WP_000028422.1
Coordinates 2433037..2433219 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7684_RS11860 (2428423) 2428423..2430084 - 1662 WP_000625088.1 terminase large subunit -
H7684_RS11865 (2430081) 2430081..2430425 - 345 WP_000402904.1 hypothetical protein -
H7684_RS11870 (2430555) 2430555..2430854 - 300 WP_000988336.1 HNH endonuclease -
H7684_RS11875 (2431086) 2431086..2431502 - 417 WP_000590122.1 hypothetical protein -
H7684_RS11880 (2431530) 2431530..2431730 - 201 WP_000265043.1 DUF1514 family protein -
H7684_RS11885 (2431730) 2431730..2431879 - 150 WP_000595265.1 transcriptional activator RinB -
H7684_RS11890 (2431876) 2431876..2432262 - 387 WP_000592207.1 hypothetical protein -
H7684_RS11895 (2432259) 2432259..2432465 - 207 WP_000195803.1 DUF1381 domain-containing protein -
H7684_RS11900 (2432502) 2432502..2433044 - 543 WP_000185659.1 dUTP pyrophosphatase -
H7684_RS11905 (2433037) 2433037..2433219 - 183 WP_000028422.1 hypothetical protein Antitoxin
H7684_RS11910 (2433209) 2433209..2433460 - 252 WP_001065091.1 DUF1024 family protein Toxin
H7684_RS11915 (2433453) 2433453..2433620 - 168 WP_001624242.1 hypothetical protein -
H7684_RS11920 (2433632) 2433632..2433874 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
H7684_RS11925 (2433878) 2433878..2434246 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
H7684_RS11930 (2434259) 2434259..2434568 - 310 Protein_2326 RusA family crossover junction endodeoxyribonuclease -
H7684_RS11935 (2434577) 2434577..2434795 - 219 WP_000338531.1 hypothetical protein -
H7684_RS11940 (2434802) 2434802..2435686 - 885 WP_000148316.1 DnaD domain protein -
H7684_RS11945 (2435716) 2435716..2436186 - 471 WP_000934764.1 single-stranded DNA-binding protein -
H7684_RS11950 (2436187) 2436187..2436804 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
H7684_RS11955 (2436885) 2436885..2437805 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2405370..2457201 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T170204 WP_001065091.1 NZ_CP060278:c2433460-2433209 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T170204 NZ_CP077198:c562794-562516 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAGCAACCGC
TGAAAAAACGGACGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCCGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT170204 WP_000028422.1 NZ_CP060278:c2433219-2433037 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT170204 NZ_CP077198:c563075-562791 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
CCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGCAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References