181128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 772693..773031 Replicon chromosome
Accession NZ_CP064389
Organism Staphylococcus aureus strain PartE-Saureus-RM8376

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag IUJ40_RS03955 Protein ID WP_011447039.1
Coordinates 772693..772869 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 772857..773031 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ40_RS03935 770474..770626 + 153 WP_001153681.1 hypothetical protein -
IUJ40_RS03940 770673..770960 + 288 WP_001040259.1 hypothetical protein -
IUJ40_RS03945 771016..771390 + 375 WP_000340977.1 hypothetical protein -
IUJ40_RS03950 771811..772584 + 774 WP_000750406.1 staphylococcal enterotoxin type A -
IUJ40_RS03955 772693..772869 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 772857..773031 - 175 - - Antitoxin
IUJ40_RS03965 773081..773335 + 255 WP_000611512.1 phage holin -
IUJ40_RS03970 773347..774102 + 756 WP_000861038.1 CHAP domain-containing protein -
IUJ40_RS03975 774293..774784 + 492 WP_000919350.1 staphylokinase -
IUJ40_RS03980 775434..775769 + 336 Protein_782 SH3 domain-containing protein -
IUJ40_RS03985 775864..776313 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
IUJ40_RS03990 776556..777728 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / sea / sak / chp / scn 716150..778681 62531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T181128 WP_011447039.1 NZ_CP064389:772693-772869 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T181128 NZ_CP085805:3944980-3945237 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 175 bp

>AT181128 NZ_CP064389:c773031-772857 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References