208083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 115414..115837 Replicon chromosome
Accession NZ_CP077852
Organism Staphylococcus aureus strain N6

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU516_RS00655 Protein ID WP_001065091.1
Coordinates 115586..115837 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU516_RS00650 Protein ID WP_000028422.1
Coordinates 115414..115596 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU516_RS00605 (110800) 110800..112461 - 1662 WP_000625088.1 terminase large subunit -
KU516_RS00610 (112458) 112458..112802 - 345 WP_000402904.1 hypothetical protein -
KU516_RS00615 (112932) 112932..113231 - 300 WP_000988336.1 HNH endonuclease -
KU516_RS00620 (113463) 113463..113879 - 417 WP_000590122.1 hypothetical protein -
KU516_RS00625 (113907) 113907..114107 - 201 WP_000265043.1 DUF1514 family protein -
KU516_RS00630 (114107) 114107..114256 - 150 WP_000595265.1 transcriptional activator RinB -
KU516_RS00635 (114253) 114253..114639 - 387 WP_000592207.1 hypothetical protein -
KU516_RS00640 (114636) 114636..114842 - 207 WP_000195803.1 DUF1381 domain-containing protein -
KU516_RS00645 (114879) 114879..115421 - 543 WP_000185659.1 dUTP pyrophosphatase -
KU516_RS00650 (115414) 115414..115596 - 183 WP_000028422.1 hypothetical protein Antitoxin
KU516_RS00655 (115586) 115586..115837 - 252 WP_001065091.1 DUF1024 family protein Toxin
KU516_RS00660 (115830) 115830..115997 - 168 WP_001624242.1 hypothetical protein -
KU516_RS00665 (116009) 116009..116251 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU516_RS00670 (116255) 116255..116623 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU516_RS00675 (116636) 116636..116945 - 310 Protein_132 RusA family crossover junction endodeoxyribonuclease -
KU516_RS00680 (116954) 116954..117172 - 219 WP_000338531.1 hypothetical protein -
KU516_RS00685 (117179) 117179..118063 - 885 WP_000148316.1 DnaD domain protein -
KU516_RS00690 (118093) 118093..118563 - 471 WP_000934764.1 single-stranded DNA-binding protein -
KU516_RS00695 (118564) 118564..119181 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU516_RS00700 (119262) 119262..120182 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / chp / sak / sea / hlb / groEL 82735..139578 56843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208083 WP_001065091.1 NZ_CP077852:c115837-115586 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208083 NZ_CP103563:c5489-5214 [Escherichia coli O25b:H4-ST131]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208083 WP_000028422.1 NZ_CP077852:c115596-115414 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208083 NZ_CP103563:c5773-5489 [Escherichia coli O25b:H4-ST131]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References