Detailed information of TA system TA208137

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 424229..424567
• Replicon: chromosome
• Accession: NZ_CP077855
• Organism: Staphylococcus aureus strain L6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU520_RS02275
• Protein ID: WP_011447039.1
• Coordinates: 424229..424405 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	424393..424567 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU520_RS02255	422010..422162	+	153	WP_001153681.1	hypothetical protein	-
KU520_RS02260	422209..422496	+	288	WP_001040259.1	hypothetical protein	-
KU520_RS02265	422552..422926	+	375	WP_000340977.1	hypothetical protein	-
KU520_RS02270	423347..424120	+	774	WP_000750406.1	staphylococcal enterotoxin type A	-
KU520_RS02275	424229..424405	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	424393..424567	-	175	-	-	Antitoxin
KU520_RS02285	424617..424871	+	255	WP_000611512.1	phage holin	-
KU520_RS02290	424883..425638	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU520_RS02295	425829..426320	+	492	WP_000919350.1	staphylokinase	-
KU520_RS02300	426970..427305	+	336	Protein_446	SH3 domain-containing protein	-
KU520_RS02305	427400..427849	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU520_RS02310	428535..428885	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU520_RS02315	428938..429198	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_009641 Staphylococcus aureus subsp. aureus str. Newman Prophage TA022266, TA022270 2089433..2146383 0.006	inside	Prophage	-	groEL / hlb / sea / sak / chp / scn	374027..428885	54858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208137 WP_011447039.1 NZ_CP077855:424229-424405 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208137 NZ_CP103579:751356-751841 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCACAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT208137 NZ_CP077855:c424567-424393 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin