Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2022656..2022963 Replicon chromosome
Accession NZ_CP125897
Organism Staphylococcus aureus strain CHAL4

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag QM341_RS10105 Protein ID WP_011447039.1
Coordinates 2022787..2022963 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2022656..2022795 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM341_RS10065 (2018223) 2018223..2018402 + 180 WP_000669791.1 hypothetical protein -
QM341_RS10070 (2018713) 2018713..2018973 + 261 WP_001791826.1 hypothetical protein -
QM341_RS10075 (2019026) 2019026..2019376 - 351 WP_000702263.1 complement inhibitor SCIN-A -
QM341_RS10080 (2019886) 2019886..2020221 - 336 Protein_1947 SH3 domain-containing protein -
QM341_RS10085 (2020872) 2020872..2021363 - 492 WP_000920038.1 staphylokinase -
QM341_RS10090 (2021554) 2021554..2022309 - 756 WP_000861038.1 CHAP domain-containing protein -
QM341_RS10095 (2022321) 2022321..2022575 - 255 WP_000611512.1 phage holin -
QM341_RS10100 (2022627) 2022627..2022734 + 108 WP_031762631.1 hypothetical protein -
- (2022656) 2022656..2022795 + 140 NuclAT_0 - Antitoxin
- (2022656) 2022656..2022795 + 140 NuclAT_0 - Antitoxin
- (2022656) 2022656..2022795 + 140 NuclAT_0 - Antitoxin
- (2022656) 2022656..2022795 + 140 NuclAT_0 - Antitoxin
QM341_RS10105 (2022787) 2022787..2022963 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
QM341_RS10110 (2023072) 2023072..2023845 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
QM341_RS10115 (2024218) 2024218..2024592 - 375 WP_000340977.1 hypothetical protein -
QM341_RS10120 (2024648) 2024648..2024935 - 288 WP_001262621.1 hypothetical protein -
QM341_RS10125 (2024981) 2024981..2025133 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / hlb / groEL 2019026..2076036 57010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T282434 WP_011447039.1 NZ_CP125897:c2022963-2022787 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 140 bp

>AT282434 NZ_CP125897:2022656-2022795 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References