Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2316103..2316410 Replicon chromosome
Accession NZ_CP023561
Organism Staphylococcus aureus strain TF3198

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag CPC18_RS11875 Protein ID WP_011447039.1
Coordinates 2316234..2316410 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2316103..2316242 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPC18_RS11815 2311669..2311848 + 180 WP_000669791.1 hypothetical protein -
CPC18_RS11825 2312159..2312419 + 261 WP_001791826.1 hypothetical protein -
CPC18_RS11830 2312472..2312822 - 351 WP_000702263.1 complement inhibitor SCIN-A -
CPC18_RS11835 2313333..2313668 - 336 Protein_2193 SH3 domain-containing protein -
CPC18_RS11855 2314319..2314810 - 492 WP_000920038.1 staphylokinase -
CPC18_RS11860 2315001..2315756 - 756 WP_148121298.1 CHAP domain-containing protein -
CPC18_RS11865 2315768..2316022 - 255 WP_000611512.1 phage holin -
CPC18_RS11870 2316074..2316181 + 108 WP_031762631.1 hypothetical protein -
- 2316103..2316242 + 140 NuclAT_0 - Antitoxin
- 2316103..2316242 + 140 NuclAT_0 - Antitoxin
- 2316103..2316242 + 140 NuclAT_0 - Antitoxin
- 2316103..2316242 + 140 NuclAT_0 - Antitoxin
CPC18_RS11875 2316234..2316410 - 177 WP_011447039.1 putative holin-like toxin Toxin
CPC18_RS11880 2316613..2317386 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
CPC18_RS11885 2317807..2318181 - 375 WP_000340977.1 hypothetical protein -
CPC18_RS11890 2318237..2318524 - 288 WP_001040255.1 hypothetical protein -
CPC18_RS11895 2318571..2318723 - 153 WP_000654329.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / see / hlb / groEL 2312472..2368275 55803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T81621 WP_011447039.1 NZ_CP023561:c2316410-2316234 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T81621 NZ_CP023561:c2316410-2316234 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT81621 NZ_CP023561:2316103-2316242 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References