209771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2609422..2609845 Replicon chromosome
Accession NZ_CP079715
Organism Staphylococcus aureus strain V8

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KX797_RS13125 Protein ID WP_001065091.1
Coordinates 2609594..2609845 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KX797_RS13120 Protein ID WP_000028422.1
Coordinates 2609422..2609604 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX797_RS13075 (2604808) 2604808..2606469 - 1662 WP_000625088.1 terminase large subunit -
KX797_RS13080 (2606466) 2606466..2606810 - 345 WP_000402904.1 hypothetical protein -
KX797_RS13085 (2606940) 2606940..2607239 - 300 WP_000988336.1 HNH endonuclease -
KX797_RS13090 (2607471) 2607471..2607887 - 417 WP_000590122.1 hypothetical protein -
KX797_RS13095 (2607915) 2607915..2608115 - 201 WP_000265043.1 DUF1514 family protein -
KX797_RS13100 (2608115) 2608115..2608264 - 150 WP_000595265.1 transcriptional activator RinB -
KX797_RS13105 (2608261) 2608261..2608647 - 387 WP_000592207.1 hypothetical protein -
KX797_RS13110 (2608644) 2608644..2608850 - 207 WP_000195803.1 DUF1381 domain-containing protein -
KX797_RS13115 (2608887) 2608887..2609429 - 543 WP_000185660.1 dUTP pyrophosphatase -
KX797_RS13120 (2609422) 2609422..2609604 - 183 WP_000028422.1 hypothetical protein Antitoxin
KX797_RS13125 (2609594) 2609594..2609845 - 252 WP_001065091.1 DUF1024 family protein Toxin
KX797_RS13130 (2609838) 2609838..2610005 - 168 WP_001624242.1 hypothetical protein -
KX797_RS13135 (2610017) 2610017..2610259 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KX797_RS13140 (2610263) 2610263..2610631 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KX797_RS13145 (2610644) 2610644..2611048 - 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
KX797_RS13150 (2611057) 2611057..2611275 - 219 WP_000338530.1 hypothetical protein -
KX797_RS13155 (2611282) 2611282..2612166 - 885 WP_000148316.1 DnaD domain protein -
KX797_RS13160 (2612196) 2612196..2612666 - 471 WP_000934764.1 single-stranded DNA-binding protein -
KX797_RS13165 (2612667) 2612667..2613284 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
KX797_RS13170 (2613365) 2613365..2614285 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2581755..2638705 56950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T209771 WP_001065091.1 NZ_CP079715:c2609845-2609594 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T209771 NZ_CP104303:c622834-622553 [Lacticaseibacillus paracasei]
ATGAATAAATTTGTTTATAAACCAGCCTTTGAACGTCAATTTAAAGAACATTACAAGACGATTTTAAAAGGGGGGCGCTA
TAAAAAAGAAGATTTTGAAGCTGTTTATCATAAACTATTACGAGATGAACCGTTAGATCCGCATTATAATGATCACGCTT
TGGTTAATCGTAAACCAGAGCGTGATTTACATATCAAGCCGGATTGGTTATTAATTTACAAATATGATGGTGAGTTTGTG
CGCTTTATCGACACGGGTTCGCATTCAGATCTTTTTAACTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT209771 WP_000028422.1 NZ_CP079715:c2609604-2609422 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT209771 NZ_CP104303:c623069-622827 [Lacticaseibacillus paracasei]
ATGACTAGCCAAGTACATTTCAGAATGAGCGAAAAAGAAAAAAAGGACTTCGAGATTGTCCTAAGTCGTGTGGGGTTAAC
TCCCGGGGAAGCTTTTCGTATCTTTGCCAAGAAATCCATTGAAGCCGGAGGAATTCCCTTTGAGGTCTCTCAGCCAAACA
CACGTTTACAAAAGGCTATTAGGAGTCAAGATTACGTTGAATTTAACGATCCTGAGGAAGGACTGGATTGGTTAAATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References