Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1987475..1987782 Replicon chromosome
Accession NZ_CP094857
Organism Staphylococcus aureus strain ATCC 29213

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag MTX75_RS09775 Protein ID WP_011447039.1
Coordinates 1987606..1987782 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1987475..1987614 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX75_RS09735 (1982813) 1982813..1983073 + 261 WP_001791826.1 hypothetical protein -
MTX75_RS09740 (1983126) 1983126..1983476 - 351 WP_000702263.1 complement inhibitor SCIN-A -
MTX75_RS09745 (1984162) 1984162..1984611 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
MTX75_RS09750 (1984706) 1984706..1985041 - 336 Protein_1882 SH3 domain-containing protein -
MTX75_RS09755 (1985691) 1985691..1986182 - 492 WP_000919350.1 staphylokinase -
MTX75_RS09760 (1986373) 1986373..1987128 - 756 WP_000861038.1 CHAP domain-containing protein -
MTX75_RS09765 (1987140) 1987140..1987394 - 255 WP_000611512.1 phage holin -
MTX75_RS09770 (1987446) 1987446..1987553 + 108 WP_001791821.1 hypothetical protein -
- (1987475) 1987475..1987614 + 140 NuclAT_0 - Antitoxin
- (1987475) 1987475..1987614 + 140 NuclAT_0 - Antitoxin
- (1987475) 1987475..1987614 + 140 NuclAT_0 - Antitoxin
- (1987475) 1987475..1987614 + 140 NuclAT_0 - Antitoxin
MTX75_RS09775 (1987606) 1987606..1987782 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
MTX75_RS09780 (1987891) 1987891..1988664 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
MTX75_RS09785 (1989085) 1989085..1989459 - 375 WP_000340977.1 hypothetical protein -
MTX75_RS09790 (1989515) 1989515..1989802 - 288 WP_001040259.1 hypothetical protein -
MTX75_RS09795 (1989849) 1989849..1990001 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 1983126..2034957 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T240698 WP_011447039.1 NZ_CP094857:c1987782-1987606 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T240698 NZ_LT615377:2773757-2774086 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 140 bp

>AT240698 NZ_CP094857:1987475-1987614 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References