208198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2655767..2656190 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU543_RS13115 Protein ID WP_001065091.1
Coordinates 2655767..2656018 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU543_RS13120 Protein ID WP_000028422.1
Coordinates 2656008..2656190 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS13070 (2651422) 2651422..2652342 + 921 WP_000138472.1 recombinase RecT -
KU543_RS13075 (2652423) 2652423..2653040 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU543_RS13080 (2653041) 2653041..2653511 + 471 WP_000934764.1 single-stranded DNA-binding protein -
KU543_RS13085 (2653541) 2653541..2654425 + 885 WP_000148316.1 DnaD domain protein -
KU543_RS13090 (2654432) 2654432..2654650 + 219 WP_000338531.1 hypothetical protein -
KU543_RS13095 (2654659) 2654659..2654968 + 310 Protein_2538 RusA family crossover junction endodeoxyribonuclease -
KU543_RS13100 (2654981) 2654981..2655349 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU543_RS13105 (2655353) 2655353..2655595 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU543_RS13110 (2655607) 2655607..2655774 + 168 WP_001624242.1 hypothetical protein -
KU543_RS13115 (2655767) 2655767..2656018 + 252 WP_001065091.1 DUF1024 family protein Toxin
KU543_RS13120 (2656008) 2656008..2656190 + 183 WP_000028422.1 hypothetical protein Antitoxin
KU543_RS13125 (2656183) 2656183..2656725 + 543 WP_000185659.1 dUTP pyrophosphatase -
KU543_RS13130 (2656762) 2656762..2656968 + 207 WP_000195803.1 DUF1381 domain-containing protein -
KU543_RS13135 (2656965) 2656965..2657351 + 387 WP_000592207.1 hypothetical protein -
KU543_RS13140 (2657348) 2657348..2657497 + 150 WP_000595265.1 transcriptional activator RinB -
KU543_RS13145 (2657497) 2657497..2657697 + 201 WP_000265043.1 DUF1514 family protein -
KU543_RS13150 (2657725) 2657725..2658141 + 417 WP_000590122.1 hypothetical protein -
KU543_RS13155 (2658373) 2658373..2658672 + 300 WP_000988336.1 HNH endonuclease -
KU543_RS13160 (2658802) 2658802..2659146 + 345 WP_000402904.1 hypothetical protein -
KU543_RS13165 (2659143) 2659143..2660804 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sea / sak / chp / scn 2636293..2683858 47565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208198 WP_001065091.1 NZ_CP077858:2655767-2656018 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208198 NZ_CP103592:186212-186319 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208198 WP_000028422.1 NZ_CP077858:2656008-2656190 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208198 NZ_CP103592:c186163-186098 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References