Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 400794..401217 Replicon chromosome
Accession NZ_CP077855
Organism Staphylococcus aureus strain L6

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU520_RS02130 Protein ID WP_001065091.1
Coordinates 400794..401045 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU520_RS02135 Protein ID WP_000028422.1
Coordinates 401035..401217 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU520_RS02085 (396449) 396449..397369 + 921 WP_000138472.1 recombinase RecT -
KU520_RS02090 (397450) 397450..398067 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU520_RS02095 (398068) 398068..398538 + 471 WP_000934764.1 single-stranded DNA-binding protein -
KU520_RS02100 (398568) 398568..399452 + 885 WP_000148316.1 DnaD domain protein -
KU520_RS02105 (399459) 399459..399677 + 219 WP_000338531.1 hypothetical protein -
KU520_RS02110 (399686) 399686..399995 + 310 Protein_407 RusA family crossover junction endodeoxyribonuclease -
KU520_RS02115 (400008) 400008..400376 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU520_RS02120 (400380) 400380..400622 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU520_RS02125 (400634) 400634..400801 + 168 WP_001624242.1 hypothetical protein -
KU520_RS02130 (400794) 400794..401045 + 252 WP_001065091.1 DUF1024 family protein Toxin
KU520_RS02135 (401035) 401035..401217 + 183 WP_000028422.1 hypothetical protein Antitoxin
KU520_RS02140 (401210) 401210..401752 + 543 WP_000185659.1 dUTP pyrophosphatase -
KU520_RS02145 (401789) 401789..401995 + 207 WP_000195803.1 DUF1381 domain-containing protein -
KU520_RS02150 (401992) 401992..402378 + 387 WP_000592207.1 hypothetical protein -
KU520_RS02155 (402375) 402375..402524 + 150 WP_000595265.1 transcriptional activator RinB -
KU520_RS02160 (402524) 402524..402724 + 201 WP_000265043.1 DUF1514 family protein -
KU520_RS02165 (402752) 402752..403168 + 417 WP_000590122.1 hypothetical protein -
KU520_RS02170 (403400) 403400..403699 + 300 WP_000988336.1 HNH endonuclease -
KU520_RS02175 (403829) 403829..404173 + 345 WP_000402904.1 hypothetical protein -
KU520_RS02180 (404170) 404170..405831 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / sea / sak / chp / scn 374027..428885 54858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208136 WP_001065091.1 NZ_CP077855:400794-401045 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208136 NZ_CP103579:328236-328604 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208136 WP_000028422.1 NZ_CP077855:401035-401217 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208136 NZ_CP103579:328018-328239 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATAGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References