Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2666675..2667013 Replicon chromosome
Accession NZ_CP077856
Organism Staphylococcus aureus strain L5

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag KU529_RS13085 Protein ID WP_011447039.1
Coordinates 2666675..2666851 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2666839..2667013 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU529_RS13065 2664456..2664608 + 153 WP_001153681.1 hypothetical protein -
KU529_RS13070 2664655..2664942 + 288 WP_001040259.1 hypothetical protein -
KU529_RS13075 2664998..2665372 + 375 WP_000340977.1 hypothetical protein -
KU529_RS13080 2665793..2666566 + 774 WP_000750406.1 staphylococcal enterotoxin type A -
KU529_RS13085 2666675..2666851 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 2666839..2667013 - 175 - - Antitoxin
KU529_RS13095 2667063..2667317 + 255 WP_000611512.1 phage holin -
KU529_RS13100 2667329..2668084 + 756 WP_000861038.1 CHAP domain-containing protein -
KU529_RS13105 2668275..2668766 + 492 WP_000919350.1 staphylokinase -
KU529_RS13110 2669416..2669751 + 336 Protein_2573 SH3 domain-containing protein -
KU529_RS13115 2669846..2670295 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
KU529_RS13120 2670981..2671331 + 351 WP_000702263.1 complement inhibitor SCIN-A -
KU529_RS13125 2671384..2671644 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sea / sak / chp / scn / hlb / map 2623766..2676342 52576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T208163 WP_011447039.1 NZ_CP077856:2666675-2666851 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T208163 NZ_CP103586:349413-349760 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 175 bp

>AT208163 NZ_CP077856:c2667013-2666839 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References