Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2005242..2005549 Replicon chromosome
Accession NZ_AP019712
Organism Staphylococcus aureus strain Tokyo12480

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag GOZ34_RS09760 Protein ID WP_011447039.1
Coordinates 2005373..2005549 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2005242..2005381 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ34_RS09720 2000581..2000841 + 261 WP_001791826.1 hypothetical protein -
GOZ34_RS09725 2000894..2001244 - 351 WP_000702263.1 complement inhibitor SCIN-A -
GOZ34_RS09730 2001929..2002378 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
GOZ34_RS09735 2002473..2002808 - 336 Protein_1871 SH3 domain-containing protein -
GOZ34_RS09740 2003458..2003949 - 492 WP_000919350.1 staphylokinase -
GOZ34_RS09745 2004140..2004895 - 756 WP_000861038.1 CHAP domain-containing protein -
GOZ34_RS09750 2004907..2005161 - 255 WP_000611512.1 phage holin -
GOZ34_RS09755 2005213..2005320 + 108 WP_001791821.1 hypothetical protein -
- 2005242..2005381 + 140 NuclAT_0 - Antitoxin
- 2005242..2005381 + 140 NuclAT_0 - Antitoxin
- 2005242..2005381 + 140 NuclAT_0 - Antitoxin
- 2005242..2005381 + 140 NuclAT_0 - Antitoxin
GOZ34_RS09760 2005373..2005549 - 177 WP_011447039.1 putative holin-like toxin Toxin
GOZ34_RS09765 2005658..2006431 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
GOZ34_RS09770 2006852..2007226 - 375 WP_000340977.1 hypothetical protein -
GOZ34_RS09775 2007282..2007569 - 288 WP_001040259.1 hypothetical protein -
GOZ34_RS09780 2007616..2007768 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2000894..2055348 54454
- flank IS/Tn - - 2008661..2008942 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T32919 WP_011447039.1 NZ_AP019712:c2005549-2005373 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T32919 NZ_AP019712:c2005549-2005373 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT32919 NZ_AP019712:2005242-2005381 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References