Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 1742169..1742468 Replicon chromosome
Accession NZ_CP041010
Organism Staphylococcus aureus strain FDAARGOS_766

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag FIU19_RS09335 Protein ID WP_011447039.1
Coordinates 1742292..1742468 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 1742169..1742224 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU19_RS09290 1737433..1738605 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
FIU19_RS09300 1738848..1739297 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
FIU19_RS09305 1739392..1739727 - 336 Protein_1699 SH3 domain-containing protein -
FIU19_RS09315 1740377..1740868 - 492 WP_000919350.1 staphylokinase -
FIU19_RS09320 1741059..1741814 - 756 WP_000861038.1 CHAP domain-containing protein -
FIU19_RS09325 1741826..1742080 - 255 WP_000611512.1 phage holin -
FIU19_RS09330 1742132..1742239 + 108 WP_001791821.1 hypothetical protein -
- 1742161..1742300 + 140 NuclAT_0 - -
- 1742161..1742300 + 140 NuclAT_0 - -
- 1742161..1742300 + 140 NuclAT_0 - -
- 1742161..1742300 + 140 NuclAT_0 - -
- 1742169..1742224 + 56 - - Antitoxin
FIU19_RS09335 1742292..1742468 - 177 WP_011447039.1 putative holin-like toxin Toxin
FIU19_RS09340 1742577..1743350 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
FIU19_RS09350 1743771..1744145 - 375 WP_000340977.1 hypothetical protein -
FIU19_RS09355 1744201..1744488 - 288 WP_001040259.1 hypothetical protein -
FIU19_RS09360 1744535..1744687 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb 1736480..1786579 50099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T127394 WP_011447039.1 NZ_CP041010:c1742468-1742292 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T127394 NZ_CP041010:c1742468-1742292 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT127394 NZ_CP041010:1742169-1742224 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References