Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2552165..2552472 Replicon chromosome
Accession NZ_CP050691
Organism Staphylococcus aureus strain PMB196-1

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag HCU71_RS12440 Protein ID WP_011447039.1
Coordinates 2552296..2552472 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2552165..2552304 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCU71_RS12400 2547503..2547763 + 261 WP_001791826.1 hypothetical protein -
HCU71_RS12405 2547816..2548166 - 351 WP_000702263.1 complement inhibitor SCIN-A -
HCU71_RS12410 2548852..2549301 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
HCU71_RS12415 2549396..2549731 - 336 Protein_2398 SH3 domain-containing protein -
HCU71_RS12420 2550381..2550872 - 492 WP_000919350.1 staphylokinase -
HCU71_RS12425 2551063..2551818 - 756 WP_000861038.1 CHAP domain-containing protein -
HCU71_RS12430 2551830..2552084 - 255 WP_000611512.1 phage holin -
HCU71_RS12435 2552136..2552243 + 108 WP_001791821.1 hypothetical protein -
- 2552165..2552304 + 140 NuclAT_0 - Antitoxin
- 2552165..2552304 + 140 NuclAT_0 - Antitoxin
- 2552165..2552304 + 140 NuclAT_0 - Antitoxin
- 2552165..2552304 + 140 NuclAT_0 - Antitoxin
HCU71_RS12440 2552296..2552472 - 177 WP_011447039.1 putative holin-like toxin Toxin
HCU71_RS12445 2552581..2553354 - 774 WP_000750406.1 staphylococcal enterotoxin type A -
HCU71_RS12450 2553775..2554149 - 375 WP_000340977.1 hypothetical protein -
HCU71_RS12455 2554205..2554492 - 288 WP_001040259.1 hypothetical protein -
HCU71_RS12460 2554539..2554691 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2547816..2599647 51831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T153113 WP_011447039.1 NZ_CP050691:c2552472-2552296 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T153113 NZ_CP066757:71918-72076 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 140 bp

>AT153113 NZ_CP050691:2552165-2552304 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References