Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 99002..99425 Replicon chromosome
Accession NZ_CP077854
Organism Staphylococcus aureus strain N4

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU508_RS00585 Protein ID WP_001065091.1
Coordinates 99174..99425 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU508_RS00580 Protein ID WP_000028422.1
Coordinates 99002..99184 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU508_RS00535 (94388) 94388..96049 - 1662 WP_000625088.1 terminase large subunit -
KU508_RS00540 (96046) 96046..96390 - 345 WP_000402904.1 hypothetical protein -
KU508_RS00545 (96520) 96520..96819 - 300 WP_000988336.1 HNH endonuclease -
KU508_RS00550 (97051) 97051..97467 - 417 WP_000590122.1 hypothetical protein -
KU508_RS00555 (97495) 97495..97695 - 201 WP_000265043.1 DUF1514 family protein -
KU508_RS00560 (97695) 97695..97844 - 150 WP_000595265.1 transcriptional activator RinB -
KU508_RS00565 (97841) 97841..98227 - 387 WP_000592207.1 hypothetical protein -
KU508_RS00570 (98224) 98224..98430 - 207 WP_000195803.1 DUF1381 domain-containing protein -
KU508_RS00575 (98467) 98467..99009 - 543 WP_000185659.1 dUTP pyrophosphatase -
KU508_RS00580 (99002) 99002..99184 - 183 WP_000028422.1 hypothetical protein Antitoxin
KU508_RS00585 (99174) 99174..99425 - 252 WP_001065091.1 DUF1024 family protein Toxin
KU508_RS00590 (99418) 99418..99585 - 168 WP_001624242.1 hypothetical protein -
KU508_RS00595 (99597) 99597..99839 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU508_RS00600 (99843) 99843..100211 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU508_RS00605 (100224) 100224..100533 - 310 Protein_121 RusA family crossover junction endodeoxyribonuclease -
KU508_RS00610 (100542) 100542..100760 - 219 WP_000338531.1 hypothetical protein -
KU508_RS00615 (100767) 100767..101651 - 885 WP_000148316.1 DnaD domain protein -
KU508_RS00620 (101681) 101681..102151 - 471 WP_000934764.1 single-stranded DNA-binding protein -
KU508_RS00625 (102152) 102152..102769 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU508_RS00630 (102850) 102850..103770 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / chp / sak / sea / hlb / groEL 66323..126191 59868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208117 WP_001065091.1 NZ_CP077854:c99425-99174 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208117 NZ_CP103570:c3970351-3970064 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208117 WP_000028422.1 NZ_CP077854:c99184-99002 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208117 NZ_CP103570:c3970077-3969775 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References