Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/- |
Location | 99002..99425 | Replicon | chromosome |
Accession | NZ_CP077854 | ||
Organism | Staphylococcus aureus strain N4 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A5S9I4Y6 |
Locus tag | KU508_RS00585 | Protein ID | WP_001065091.1 |
Coordinates | 99174..99425 (-) | Length | 84 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A0E0VQM8 |
Locus tag | KU508_RS00580 | Protein ID | WP_000028422.1 |
Coordinates | 99002..99184 (-) | Length | 61 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KU508_RS00535 (94388) | 94388..96049 | - | 1662 | WP_000625088.1 | terminase large subunit | - |
KU508_RS00540 (96046) | 96046..96390 | - | 345 | WP_000402904.1 | hypothetical protein | - |
KU508_RS00545 (96520) | 96520..96819 | - | 300 | WP_000988336.1 | HNH endonuclease | - |
KU508_RS00550 (97051) | 97051..97467 | - | 417 | WP_000590122.1 | hypothetical protein | - |
KU508_RS00555 (97495) | 97495..97695 | - | 201 | WP_000265043.1 | DUF1514 family protein | - |
KU508_RS00560 (97695) | 97695..97844 | - | 150 | WP_000595265.1 | transcriptional activator RinB | - |
KU508_RS00565 (97841) | 97841..98227 | - | 387 | WP_000592207.1 | hypothetical protein | - |
KU508_RS00570 (98224) | 98224..98430 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
KU508_RS00575 (98467) | 98467..99009 | - | 543 | WP_000185659.1 | dUTP pyrophosphatase | - |
KU508_RS00580 (99002) | 99002..99184 | - | 183 | WP_000028422.1 | hypothetical protein | Antitoxin |
KU508_RS00585 (99174) | 99174..99425 | - | 252 | WP_001065091.1 | DUF1024 family protein | Toxin |
KU508_RS00590 (99418) | 99418..99585 | - | 168 | WP_001624242.1 | hypothetical protein | - |
KU508_RS00595 (99597) | 99597..99839 | - | 243 | WP_000131366.1 | SAV1978 family virulence-associated passenger protein | - |
KU508_RS00600 (99843) | 99843..100211 | - | 369 | WP_000101274.1 | SA1788 family PVL leukocidin-associated protein | - |
KU508_RS00605 (100224) | 100224..100533 | - | 310 | Protein_121 | RusA family crossover junction endodeoxyribonuclease | - |
KU508_RS00610 (100542) | 100542..100760 | - | 219 | WP_000338531.1 | hypothetical protein | - |
KU508_RS00615 (100767) | 100767..101651 | - | 885 | WP_000148316.1 | DnaD domain protein | - |
KU508_RS00620 (101681) | 101681..102151 | - | 471 | WP_000934764.1 | single-stranded DNA-binding protein | - |
KU508_RS00625 (102152) | 102152..102769 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
KU508_RS00630 (102850) | 102850..103770 | - | 921 | WP_000138472.1 | recombinase RecT | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | map / hlb / scn / chp / sak / sea / hlb / groEL | 66323..126191 | 59868 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9349.22 Da Isoelectric Point: 3.9473
>T208117 WP_001065091.1 NZ_CP077854:c99425-99174 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T208117 NZ_CP103570:c3970351-3970064 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 61 a.a. Molecular weight: 6741.63 Da Isoelectric Point: 4.2658
>AT208117 WP_000028422.1 NZ_CP077854:c99184-99002 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
Download Length: 183 bp
>AT208117 NZ_CP103570:c3970077-3969775 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5S9I4Y6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VQM8 |