Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2643240..2643663 Replicon chromosome
Accession NZ_CP077856
Organism Staphylococcus aureus strain L5

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU529_RS12940 Protein ID WP_001065091.1
Coordinates 2643240..2643491 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU529_RS12945 Protein ID WP_000028422.1
Coordinates 2643481..2643663 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU529_RS12895 (2638895) 2638895..2639815 + 921 WP_000138472.1 recombinase RecT -
KU529_RS12900 (2639896) 2639896..2640513 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU529_RS12905 (2640514) 2640514..2640984 + 471 WP_000934764.1 single-stranded DNA-binding protein -
KU529_RS12910 (2641014) 2641014..2641898 + 885 WP_000148316.1 DnaD domain protein -
KU529_RS12915 (2641905) 2641905..2642123 + 219 WP_000338531.1 hypothetical protein -
KU529_RS12920 (2642132) 2642132..2642441 + 310 Protein_2534 RusA family crossover junction endodeoxyribonuclease -
KU529_RS12925 (2642454) 2642454..2642822 + 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU529_RS12930 (2642826) 2642826..2643068 + 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU529_RS12935 (2643080) 2643080..2643247 + 168 WP_001624242.1 hypothetical protein -
KU529_RS12940 (2643240) 2643240..2643491 + 252 WP_001065091.1 DUF1024 family protein Toxin
KU529_RS12945 (2643481) 2643481..2643663 + 183 WP_000028422.1 hypothetical protein Antitoxin
KU529_RS12950 (2643656) 2643656..2644198 + 543 WP_000185659.1 dUTP pyrophosphatase -
KU529_RS12955 (2644235) 2644235..2644441 + 207 WP_000195803.1 DUF1381 domain-containing protein -
KU529_RS12960 (2644438) 2644438..2644824 + 387 WP_000592207.1 hypothetical protein -
KU529_RS12965 (2644821) 2644821..2644970 + 150 WP_000595265.1 transcriptional activator RinB -
KU529_RS12970 (2644970) 2644970..2645170 + 201 WP_000265043.1 DUF1514 family protein -
KU529_RS12975 (2645198) 2645198..2645614 + 417 WP_000590122.1 hypothetical protein -
KU529_RS12980 (2645846) 2645846..2646145 + 300 WP_000988336.1 HNH endonuclease -
KU529_RS12985 (2646275) 2646275..2646619 + 345 WP_000402904.1 hypothetical protein -
KU529_RS12990 (2646616) 2646616..2648277 + 1662 WP_000625088.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlb / sea / sak / chp / scn / hlb / map 2623766..2676342 52576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208162 WP_001065091.1 NZ_CP077856:2643240-2643491 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208162 NZ_CP103586:323452-323820 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208162 WP_000028422.1 NZ_CP077856:2643481-2643663 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208162 NZ_CP103586:323234-323455 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References