Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2029786..2030209 Replicon chromosome
Accession NZ_AP019712
Organism Staphylococcus aureus strain Tokyo12480

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag GOZ34_RS09910 Protein ID WP_001065091.1
Coordinates 2029958..2030209 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag GOZ34_RS09905 Protein ID WP_000028422.1
Coordinates 2029786..2029968 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ34_RS09860 2025172..2026833 - 1662 WP_000625088.1 terminase large subunit -
GOZ34_RS09865 2026830..2027174 - 345 WP_000402904.1 hypothetical protein -
GOZ34_RS09870 2027304..2027603 - 300 WP_000988336.1 HNH endonuclease -
GOZ34_RS09875 2027835..2028251 - 417 WP_000590122.1 hypothetical protein -
GOZ34_RS09880 2028279..2028479 - 201 WP_000265043.1 DUF1514 family protein -
GOZ34_RS09885 2028479..2028628 - 150 WP_000595265.1 transcriptional activator RinB -
GOZ34_RS09890 2028625..2029011 - 387 WP_000592207.1 hypothetical protein -
GOZ34_RS09895 2029008..2029214 - 207 WP_000195803.1 DUF1381 domain-containing protein -
GOZ34_RS09900 2029251..2029793 - 543 WP_000185660.1 dUTP pyrophosphatase -
GOZ34_RS09905 2029786..2029968 - 183 WP_000028422.1 hypothetical protein Antitoxin
GOZ34_RS09910 2029958..2030209 - 252 WP_001065091.1 DUF1024 family protein Toxin
GOZ34_RS13620 2030202..2030369 - 168 WP_001624242.1 hypothetical protein -
GOZ34_RS09915 2030381..2030623 - 243 WP_000131366.1 hypothetical protein -
GOZ34_RS09920 2030627..2030995 - 369 WP_000101274.1 hypothetical protein -
GOZ34_RS09925 2031008..2031412 - 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
GOZ34_RS09930 2031421..2031639 - 219 WP_000338530.1 hypothetical protein -
GOZ34_RS09935 2031646..2032530 - 885 WP_000148316.1 DnaD domain protein -
GOZ34_RS09940 2032560..2033030 - 471 WP_000934764.1 single-stranded DNA-binding protein -
GOZ34_RS09945 2033031..2033648 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
GOZ34_RS09950 2033729..2034649 - 921 WP_155978247.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / sea / hlb / groEL 2000894..2055348 54454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T32922 WP_001065091.1 NZ_AP019712:c2030209-2029958 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T32922 NZ_AP019712:c2030209-2029958 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT32922 WP_000028422.1 NZ_AP019712:c2029968-2029786 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT32922 NZ_AP019712:c2029968-2029786 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References