30448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 11352..11899 Replicon plasmid pIFM3804
Accession NC_023329
Organism Escherichia coli

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HTE28_RS00070 Protein ID WP_244442846.1
Coordinates 11621..11899 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HTE28_RS00065 Protein ID WP_000079941.1
Coordinates 11352..11621 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTE28_RS00045 7170..7475 - 306 WP_001255015.1 LysR family transcriptional regulator -
HTE28_RS00050 7503..8717 - 1215 WP_000214121.1 chloramphenicol/florfenicol efflux MFS transporter FloR -
HTE28_RS00600 8934..9818 - 885 WP_001447541.1 DUF3363 domain-containing protein -
HTE28_RS00060 9849..10994 - 1146 Protein_9 IS91-like element ISVsa3 family transposase -
HTE28_RS00065 (D616_p112128) 11352..11621 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
HTE28_RS00070 (D616_p112127) 11621..11899 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
HTE28_RS00075 (D616_p112126) 11939..12787 + 849 WP_021265674.1 3'-5' exonuclease -
HTE28_RS00080 (D616_p112125) 12928..13377 + 450 WP_001236003.1 hypothetical protein -
HTE28_RS00085 (D616_p112122) 13854..14120 - 267 WP_000955263.1 hypothetical protein -
HTE28_RS00090 (D616_p112121) 14120..14614 - 495 WP_001459505.1 hypothetical protein -
HTE28_RS00095 (D616_p112120) 14670..15272 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid sul2 / floR / blaCTX-M-1 - 1..104399 104399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T30448 WP_244442846.1 NC_023329:11621-11899 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T30448 NC_023329:11621-11899 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT30448 WP_000079941.1 NC_023329:11352-11621 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT30448 NC_023329:11352-11621 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References