177094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 59679..59943 Replicon plasmid unnamed476
Accession NZ_CP062877
Organism Escherichia coli O157:H16 strain Res13-Lact-PEA12-26

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag IMP69_RS23725 Protein ID WP_001331364.1
Coordinates 59791..59943 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 59679..59736 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP69_RS23710 54918..57209 - 2292 WP_001289276.1 hypothetical protein -
IMP69_RS23715 57202..58272 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
IMP69_RS23720 58291..59499 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 59679..59736 - 58 NuclAT_0 - Antitoxin
- 59679..59736 - 58 NuclAT_0 - Antitoxin
- 59679..59736 - 58 NuclAT_0 - Antitoxin
- 59679..59736 - 58 NuclAT_0 - Antitoxin
IMP69_RS23725 59791..59943 + 153 WP_001331364.1 Hok/Gef family protein Toxin
IMP69_RS23730 60015..60266 - 252 WP_001291964.1 hypothetical protein -
IMP69_RS23735 60925..61101 - 177 WP_001054904.1 hypothetical protein -
IMP69_RS23740 61493..61702 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
IMP69_RS23745 61774..62424 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
IMP69_RS23750 62498..64666 - 2169 WP_021537350.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA17 / aadA5 / sul2 / blaCTX-M-1 - 1..109586 109586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T177094 WP_001331364.1 NZ_CP062877:59791-59943 [Escherichia coli O157:H16]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T177094 NZ_CP083075:c4960319-4960035 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 58 bp

>AT177094 NZ_CP062877:c59736-59679 [Escherichia coli O157:H16]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References