Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 62169..62433 Replicon plasmid unnamed476
Accession NZ_CP062907
Organism Escherichia coli strain Res13-Lact-EB12-05

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag IMP23_RS00940 Protein ID WP_001331364.1
Coordinates 62281..62433 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 62169..62226 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP23_RS00925 57408..59699 - 2292 WP_001289276.1 hypothetical protein -
IMP23_RS00930 59692..60762 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
IMP23_RS00935 60781..61989 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 62169..62226 - 58 NuclAT_0 - Antitoxin
- 62169..62226 - 58 NuclAT_0 - Antitoxin
- 62169..62226 - 58 NuclAT_0 - Antitoxin
- 62169..62226 - 58 NuclAT_0 - Antitoxin
IMP23_RS00940 62281..62433 + 153 WP_001331364.1 Hok/Gef family protein Toxin
IMP23_RS00945 62505..62756 - 252 WP_001291964.1 hypothetical protein -
IMP23_RS00950 63415..63591 - 177 WP_001054904.1 hypothetical protein -
IMP23_RS00955 63983..64192 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
IMP23_RS00960 64264..64914 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
IMP23_RS00965 64988..67156 - 2169 WP_021537350.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA17 / aadA5 / sul2 / blaCTX-M-1 - 1..112076 112076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T177249 WP_001331364.1 NZ_CP062907:62281-62433 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T177249 NZ_CP083369:c13924-13649 [Pseudomonas aeruginosa]
ATGGAATTGAAGTGGACAAGCAAGGCGCTTTCCGACATTACCCGACTGTACGAGTTTCTTGCCACGGTGAATCAGCCTGC
CGCCGCACGAACAGTGCAGCAACTCACAGCCGCACCTACCACGCTGCTGACCAACCCGCGCATTGGCGAACGGCTGGAAG
AGTTCGAGCCAAGGGATGTACGCCGAATTCAGATCGGCCAATACGAGATGCGTTACGAGATAGTGGATTCCACTATCTAC
CTGCTGCGCCTGTGGCACACCCGCGAAGACCGATAG

Antitoxin


Download         Length: 58 bp

>AT177249 NZ_CP062907:c62226-62169 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References