Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid p573-3
Accession NZ_CP102856
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NWH85_RS24940 Protein ID WP_244442846.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag NWH85_RS24935 Protein ID WP_000079941.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS24925 (46) 46..1077 + 1032 WP_000907870.1 plasmid replication initiator RepA -
NWH85_RS24930 (1773) 1773..1931 + 159 WP_000841008.1 hypothetical protein -
NWH85_RS24935 (1986) 1986..2255 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NWH85_RS24940 (2255) 2255..2533 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
NWH85_RS24945 (2573) 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
NWH85_RS24950 (3538) 3538..4011 + 474 WP_001334658.1 hypothetical protein -
NWH85_RS24955 (4488) 4488..4754 - 267 WP_000955263.1 hypothetical protein -
NWH85_RS24960 (4754) 4754..4939 - 186 Protein_7 hypothetical protein -
NWH85_RS24965 (4972) 4972..6486 - 1515 Protein_8 Tn3-like element TnAs1 family transposase -
NWH85_RS24970 (6552) 6552..7256 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid mph(A) / fosA3 / blaCTX-M-123 - 1..114525 114525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T254316 WP_244442846.1 NZ_CP102856:2255-2533 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT254316 WP_000079941.1 NZ_CP102856:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References