254317

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 30437..30930 Replicon plasmid p573-3
Accession NZ_CP102856
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag NWH85_RS25120 Protein ID WP_001230709.1
Coordinates 30676..30930 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag NWH85_RS25115 Protein ID WP_000151456.1
Coordinates 30437..30679 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS25090 (26074) 26074..26328 - 255 WP_000678527.1 hypothetical protein -
NWH85_RS25095 (26373) 26373..27299 - 927 WP_001290416.1 hypothetical protein -
NWH85_RS25100 (27531) 27531..28793 + 1263 WP_000608644.1 IS1380-like element ISEcp1 family transposase -
NWH85_RS25105 (29046) 29046..29921 + 876 WP_031942271.1 extended-spectrum class A beta-lactamase CTX-M-123 -
NWH85_RS25110 (29968) 29968..30312 - 345 Protein_37 WbuC family cupin fold metalloprotein -
NWH85_RS25115 (30437) 30437..30679 - 243 WP_000151456.1 hypothetical protein Antitoxin
NWH85_RS25120 (30676) 30676..30930 - 255 WP_001230709.1 hypothetical protein Toxin
NWH85_RS25125 (30927) 30927..31469 - 543 WP_001083904.1 hypothetical protein -
NWH85_RS25130 (31573) 31573..32088 - 516 WP_001025393.1 J domain-containing protein -
NWH85_RS25135 (32492) 32492..32821 - 330 WP_000855119.1 hypothetical protein -
NWH85_RS25140 (33636) 33636..34049 + 414 WP_000465036.1 hypothetical protein -
NWH85_RS25145 (34051) 34051..34830 + 780 WP_001164198.1 site-specific integrase -
NWH85_RS25150 (35010) 35010..35654 + 645 WP_001144036.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid mph(A) / fosA3 / blaCTX-M-123 - 1..114525 114525
- flank IS/Tn blaCTX-M-123 - 27531..29921 2390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T254317 WP_001230709.1 NZ_CP102856:c30930-30676 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT254317 WP_000151456.1 NZ_CP102856:c30679-30437 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References