Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 62386..62650 Replicon plasmid unnamed476
Accession NZ_CP062903
Organism Escherichia coli O152:H23 strain Res13-Lact-ER01-35

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag IMP37_RS23880 Protein ID WP_001331364.1
Coordinates 62498..62650 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 62386..62443 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP37_RS23865 57625..59916 - 2292 WP_001289276.1 hypothetical protein -
IMP37_RS23870 59909..60979 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
IMP37_RS23875 60998..62206 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 62386..62443 - 58 NuclAT_0 - Antitoxin
- 62386..62443 - 58 NuclAT_0 - Antitoxin
- 62386..62443 - 58 NuclAT_0 - Antitoxin
- 62386..62443 - 58 NuclAT_0 - Antitoxin
IMP37_RS23880 62498..62650 + 153 WP_001331364.1 Hok/Gef family protein Toxin
IMP37_RS23885 62722..62973 - 252 WP_001291964.1 hypothetical protein -
IMP37_RS23890 63632..63808 - 177 WP_001054904.1 hypothetical protein -
IMP37_RS23895 64200..64409 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
IMP37_RS23900 64481..65131 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
IMP37_RS23905 65205..67373 - 2169 WP_021537350.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid aadA5 / sul2 / blaCTX-M-1 - 1..112293 112293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T177244 WP_001331364.1 NZ_CP062903:62498-62650 [Escherichia coli O152:H23]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T177244 NZ_CP083366:c5599142-5598852 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 58 bp

>AT177244 NZ_CP062903:c62443-62386 [Escherichia coli O152:H23]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References