177248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 16906..17453 Replicon plasmid unnamed476
Accession NZ_CP062907
Organism Escherichia coli strain Res13-Lact-EB12-05

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag IMP23_RS00655 Protein ID WP_000970007.1
Coordinates 17172..17453 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag IMP23_RS00650 Protein ID WP_000079941.1
Coordinates 16906..17175 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP23_RS00620 12580..13335 + 756 Protein_13 IS110-like element IS5075 family transposase -
IMP23_RS00625 13517..13693 - 177 WP_000954592.1 Arm DNA-binding domain-containing protein -
IMP23_RS00630 14023..14838 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
IMP23_RS00635 14925..15167 + 243 Protein_16 phosphoglucosamine mutase -
IMP23_RS00640 15121..15372 - 252 WP_001445143.1 hypothetical protein -
IMP23_RS00645 15403..16539 - 1137 WP_023140202.1 IS91 family transposase -
IMP23_RS00650 16906..17175 + 270 WP_000079941.1 hypothetical protein Antitoxin
IMP23_RS00655 17172..17453 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMP23_RS00660 17493..18341 + 849 WP_021265674.1 3'-5' exonuclease -
IMP23_RS00665 18458..18931 + 474 WP_001334658.1 hypothetical protein -
IMP23_RS00670 19408..19674 - 267 WP_000955263.1 hypothetical protein -
IMP23_RS00675 19674..20168 - 495 WP_001459505.1 hypothetical protein -
IMP23_RS00680 20224..20826 - 603 WP_000517695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA17 / aadA5 / sul2 / blaCTX-M-1 - 1..112076 112076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T177248 WP_000970007.1 NZ_CP062907:17172-17453 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T177248 NZ_CP083369:7898-8275 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT177248 WP_000079941.1 NZ_CP062907:16906-17175 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT177248 NZ_CP083369:8256-8591 [Pseudomonas aeruginosa]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References