157841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 15602..16149 Replicon plasmid pJ31
Accession NZ_CP053788
Organism Escherichia coli isolate J31

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag HQN81_RS23545 Protein ID WP_000970007.1
Coordinates 15868..16149 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HQN81_RS23540 Protein ID WP_000079941.1
Coordinates 15602..15871 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN81_RS23510 11276..12031 + 756 Protein_11 IS110-like element IS5075 family transposase -
HQN81_RS23515 12213..12389 - 177 WP_000954592.1 Arm DNA-binding domain-containing protein -
HQN81_RS23520 12719..13534 + 816 WP_001043265.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
HQN81_RS23525 13621..13923 + 303 WP_000251875.1 phosphoglucosamine mutase -
HQN81_RS23530 13817..14068 - 252 WP_001445143.1 hypothetical protein -
HQN81_RS23535 14099..15235 - 1137 WP_023140202.1 IS91 family transposase -
HQN81_RS23540 15602..15871 + 270 WP_000079941.1 hypothetical protein Antitoxin
HQN81_RS23545 15868..16149 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQN81_RS23550 16189..17037 + 849 WP_021265674.1 3'-5' exonuclease -
HQN81_RS23555 17154..17627 + 474 WP_001334658.1 hypothetical protein -
HQN81_RS23560 18104..18370 - 267 WP_000955263.1 hypothetical protein -
HQN81_RS23565 18370..18864 - 495 WP_001459505.1 hypothetical protein -
HQN81_RS23570 18920..19522 - 603 WP_000517695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA17 / aadA5 / sul2 / blaCTX-M-1 - 1..108661 108661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T157841 WP_000970007.1 NZ_CP053788:15868-16149 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T157841 NZ_CP069488:c3864594-3864217 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT157841 WP_000079941.1 NZ_CP053788:15602-15871 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT157841 NZ_CP069488:c3865052-3864684 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References