277599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 61961..62508 Replicon plasmid unnamed2
Accession NZ_CP122662
Organism Escherichia coli strain ETEC4073

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDY26_RS24310 Protein ID WP_244442846.1
Coordinates 62230..62508 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QDY26_RS24305 Protein ID WP_000079941.1
Coordinates 61961..62230 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY26_RS24285 (57236) 57236..57940 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
QDY26_RS24290 (58073) 58073..59296 + 1224 WP_085286200.1 macrolide efflux MFS transporter Mef(C) -
QDY26_RS24295 (59301) 59301..60185 + 885 WP_014386803.1 Mph(G) family macrolide 2'-phosphotransferase -
QDY26_RS24300 (60458) 60458..61603 - 1146 Protein_60 IS91-like element ISVsa3 family transposase -
QDY26_RS24305 (61961) 61961..62230 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDY26_RS24310 (62230) 62230..62508 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
QDY26_RS24315 (62548) 62548..63396 + 849 WP_021265674.1 3'-5' exonuclease -
QDY26_RS24320 (63513) 63513..63986 + 474 WP_001334658.1 hypothetical protein -
QDY26_RS24325 (64463) 64463..64729 - 267 WP_000955263.1 hypothetical protein -
QDY26_RS24330 (64729) 64729..65223 - 495 WP_001459505.1 hypothetical protein -
QDY26_RS24335 (65279) 65279..65881 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid mef(C) / mph(G) - 1..102120 102120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T277599 WP_244442846.1 NZ_CP122662:62230-62508 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT277599 WP_000079941.1 NZ_CP122662:61961-62230 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References