Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 11983..12530 Replicon plasmid pKFu022_1
Accession NZ_CP091678
Organism Escherichia coli strain KFu022

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag L6L66_RS22860 Protein ID WP_244442846.1
Coordinates 12252..12530 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag L6L66_RS22855 Protein ID WP_000079941.1
Coordinates 11983..12252 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L66_RS22830 (7657) 7657..8412 + 756 Protein_9 IS110-like element IS5075 family transposase -
L6L66_RS22835 (8684) 8684..8770 - 87 Protein_10 Arm DNA-binding domain-containing protein -
L6L66_RS22840 (9100) 9100..9915 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
L6L66_RS22845 (10002) 10002..10244 + 243 Protein_12 phosphoglucosamine mutase -
L6L66_RS22850 (10480) 10480..11625 - 1146 Protein_13 IS91-like element ISVsa3 family transposase -
L6L66_RS22855 (11983) 11983..12252 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
L6L66_RS22860 (12252) 12252..12530 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
L6L66_RS22865 (12570) 12570..13418 + 849 WP_021265674.1 3'-5' exonuclease -
L6L66_RS22870 (13535) 13535..14008 + 474 WP_001334658.1 hypothetical protein -
L6L66_RS22875 (14485) 14485..14751 - 267 WP_000955263.1 hypothetical protein -
L6L66_RS22880 (14751) 14751..15245 - 495 WP_001459505.1 hypothetical protein -
L6L66_RS22885 (15301) 15301..15903 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid tet(A) / sul2 / blaCTX-M-1 - 1..108771 108771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T234482 WP_244442846.1 NZ_CP091678:12252-12530 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T234482 NZ_LR130545:c4225588-4225304 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT234482 WP_000079941.1 NZ_CP091678:11983-12252 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT234482 NZ_LR130545:c4225824-4225591 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References