Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 57464..57728 | Replicon | plasmid unnamed3 |
Accession | NZ_CP081194 | ||
Organism | Escherichia coli strain EC1722-1 |
Toxin (Protein)
Gene name | pndA | Uniprot ID | E6BRV3 |
Locus tag | K4F91_RS25465 | Protein ID | WP_001303307.1 |
Coordinates | 57576..57728 (+) | Length | 51 a.a. |
Antitoxin (RNA)
Gene name | pndB | ||
Locus tag | - | ||
Coordinates | 57464..57526 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K4F91_RS25450 (52703) | 52703..54994 | - | 2292 | WP_072800778.1 | F-type conjugative transfer protein TrbC | - |
K4F91_RS25455 (54987) | 54987..56057 | - | 1071 | WP_052895276.1 | IncI1-type conjugal transfer protein TrbB | - |
K4F91_RS25460 (56076) | 56076..57284 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
- (57464) | 57464..57526 | - | 63 | NuclAT_0 | - | Antitoxin |
- (57464) | 57464..57526 | - | 63 | NuclAT_0 | - | Antitoxin |
- (57464) | 57464..57526 | - | 63 | NuclAT_0 | - | Antitoxin |
- (57464) | 57464..57526 | - | 63 | NuclAT_0 | - | Antitoxin |
K4F91_RS25465 (57576) | 57576..57728 | + | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin |
K4F91_RS25470 (57800) | 57800..58051 | - | 252 | WP_001291965.1 | hypothetical protein | - |
- (58438) | 58438..58489 | - | 52 | NuclAT_1 | - | - |
- (58438) | 58438..58489 | - | 52 | NuclAT_1 | - | - |
- (58438) | 58438..58489 | - | 52 | NuclAT_1 | - | - |
- (58438) | 58438..58489 | - | 52 | NuclAT_1 | - | - |
K4F91_RS25475 (59329) | 59329..59466 | - | 138 | WP_049290858.1 | hypothetical protein | - |
K4F91_RS25480 (59511) | 59511..60737 | - | 1227 | WP_052895285.1 | RNA-guided endonuclease TnpB family protein | - |
K4F91_RS25485 (61379) | 61379..61588 | + | 210 | WP_052895278.1 | HEAT repeat domain-containing protein | - |
K4F91_RS25490 (61660) | 61660..62322 | - | 663 | WP_052895279.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Conjugative plasmid | sul2 / floR | - | 1..105553 | 105553 | ||
- | flank | IS/Tn | - | - | 59511..60743 | 1232 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.21 Da Isoelectric Point: 8.7948
>T212722 WP_001303307.1 NZ_CP081194:57576-57728 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T212722 NZ_CP107335:56133-56444 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
Antitoxin
Download Length: 63 bp
>AT212722 NZ_CP081194:c57526-57464 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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