Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 15602..16149 Replicon plasmid p2-101
Accession NZ_CP053786
Organism Escherichia coli isolate 2-101

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag HQN80_RS22895 Protein ID WP_000970007.1
Coordinates 15868..16149 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag HQN80_RS22890 Protein ID WP_000079941.1
Coordinates 15602..15871 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN80_RS22860 11276..12031 + 756 Protein_11 IS110-like element IS5075 family transposase -
HQN80_RS22865 12213..12389 - 177 WP_000954592.1 Arm DNA-binding domain-containing protein -
HQN80_RS22870 12719..13534 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
HQN80_RS22875 13621..13923 + 303 WP_000251875.1 phosphoglucosamine mutase -
HQN80_RS22880 13817..14068 - 252 WP_001445143.1 hypothetical protein -
HQN80_RS22885 14099..15235 - 1137 WP_023140202.1 IS91 family transposase -
HQN80_RS22890 15602..15871 + 270 WP_000079941.1 hypothetical protein Antitoxin
HQN80_RS22895 15868..16149 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQN80_RS22900 16189..17037 + 849 WP_021265674.1 3'-5' exonuclease -
HQN80_RS22905 17154..17627 + 474 WP_001334658.1 hypothetical protein -
HQN80_RS22910 18104..18370 - 267 WP_000955263.1 hypothetical protein -
HQN80_RS22915 18370..18864 - 495 WP_001459505.1 hypothetical protein -
HQN80_RS22920 18920..19522 - 603 WP_000517695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA17 / aadA5 / sul2 / blaCTX-M-1 - 1..108661 108661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T157815 WP_000970007.1 NZ_CP053786:15868-16149 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T157815 NZ_CP069480:4902871-4902973 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT157815 WP_000079941.1 NZ_CP053786:15602-15871 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT157815 NZ_CP069480:c4903011-4902743 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References