250695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 18011..18558 Replicon plasmid pLH50-c-B
Accession NZ_CP100502
Organism Escherichia coli strain LH50-c

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NLZ13_RS27885 Protein ID WP_244442846.1
Coordinates 18280..18558 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag NLZ13_RS27880 Protein ID WP_000079941.1
Coordinates 18011..18280 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ13_RS27855 (14247) 14247..14660 - 414 Protein_11 IS91 family transposase -
NLZ13_RS27860 (14641) 14641..14913 - 273 WP_000019163.1 hypothetical protein -
NLZ13_RS27865 (15128) 15128..15943 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
NLZ13_RS27870 (16030) 16030..16272 + 243 Protein_14 phosphoglucosamine mutase -
NLZ13_RS27875 (16508) 16508..17653 - 1146 Protein_15 IS91-like element ISVsa3 family transposase -
NLZ13_RS27880 (18011) 18011..18280 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NLZ13_RS27885 (18280) 18280..18558 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
NLZ13_RS27890 (18598) 18598..19446 + 849 WP_021265674.1 3'-5' exonuclease -
NLZ13_RS27895 (19587) 19587..20036 + 450 WP_001236003.1 hypothetical protein -
NLZ13_RS27900 (20513) 20513..20779 - 267 WP_000955263.1 hypothetical protein -
NLZ13_RS27905 (20779) 20779..21273 - 495 WP_001459505.1 hypothetical protein -
NLZ13_RS27910 (21329) 21329..21931 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA1 / blaTEM-1B / sul2 - 1..112293 112293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T250695 WP_244442846.1 NZ_CP100502:18280-18558 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT250695 WP_000079941.1 NZ_CP100502:18011-18280 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References