177299

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 60456..60720 Replicon plasmid unnamed476
Accession NZ_CP062913
Organism Escherichia coli O112ab:H8 strain Res13-Lact-EA06-22

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag IMP05_RS24355 Protein ID WP_001331364.1
Coordinates 60568..60720 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 60456..60513 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP05_RS24340 55695..57986 - 2292 WP_001289276.1 hypothetical protein -
IMP05_RS24345 57979..59049 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
IMP05_RS24350 59068..60276 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 60456..60513 - 58 NuclAT_0 - Antitoxin
- 60456..60513 - 58 NuclAT_0 - Antitoxin
- 60456..60513 - 58 NuclAT_0 - Antitoxin
- 60456..60513 - 58 NuclAT_0 - Antitoxin
IMP05_RS24355 60568..60720 + 153 WP_001331364.1 Hok/Gef family protein Toxin
IMP05_RS24360 60792..61043 - 252 WP_001291964.1 hypothetical protein -
IMP05_RS24365 61702..61878 - 177 WP_001054904.1 hypothetical protein -
IMP05_RS24370 62270..62479 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
IMP05_RS24375 62551..63201 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
IMP05_RS24380 63275..65443 - 2169 WP_021537350.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA17 / aadA5 / sul2 / blaCTX-M-1 - 1..110368 110368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T177299 WP_001331364.1 NZ_CP062913:60568-60720 [Escherichia coli O112ab:H8]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T177299 NZ_CP083434:c1015592-1015272 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin


Download         Length: 58 bp

>AT177299 NZ_CP062913:c60513-60456 [Escherichia coli O112ab:H8]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References