Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 60102..60366 Replicon plasmid unnamed476
Accession NZ_CP062869
Organism Escherichia coli strain Res13-Lact-PEB01-20

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag IMP84_RS22710 Protein ID WP_001331364.1
Coordinates 60214..60366 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 60102..60159 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMP84_RS22695 55341..57632 - 2292 WP_001289276.1 hypothetical protein -
IMP84_RS22700 57625..58695 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
IMP84_RS22705 58714..59922 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 60102..60159 - 58 NuclAT_0 - Antitoxin
- 60102..60159 - 58 NuclAT_0 - Antitoxin
- 60102..60159 - 58 NuclAT_0 - Antitoxin
- 60102..60159 - 58 NuclAT_0 - Antitoxin
IMP84_RS22710 60214..60366 + 153 WP_001331364.1 Hok/Gef family protein Toxin
IMP84_RS22715 60438..60689 - 252 WP_001291964.1 hypothetical protein -
IMP84_RS22720 61348..61524 - 177 WP_001054904.1 hypothetical protein -
IMP84_RS22725 61916..62125 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
IMP84_RS22730 62197..62847 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
IMP84_RS22735 62921..65089 - 2169 WP_021537350.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid aadA5 / sul2 / blaCTX-M-1 - 1..112549 112549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T177025 WP_001331364.1 NZ_CP062869:60214-60366 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T177025 NZ_CP083051:1828599-1828701 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT177025 NZ_CP062869:c60159-60102 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References