250844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 20871..21418 Replicon plasmid pLH09-a-B
Accession NZ_CP100546
Organism Escherichia coli strain LH09-a

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NLZ06_RS23185 Protein ID WP_244442846.1
Coordinates 21140..21418 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag NLZ06_RS23180 Protein ID WP_000079941.1
Coordinates 20871..21140 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLZ06_RS23155 (17107) 17107..17520 - 414 Protein_14 IS91 family transposase -
NLZ06_RS23160 (17501) 17501..17773 - 273 WP_000019163.1 hypothetical protein -
NLZ06_RS23165 (17988) 17988..18803 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
NLZ06_RS23170 (18890) 18890..19132 + 243 Protein_17 phosphoglucosamine mutase -
NLZ06_RS23175 (19368) 19368..20513 - 1146 Protein_18 IS91-like element ISVsa3 family transposase -
NLZ06_RS23180 (20871) 20871..21140 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NLZ06_RS23185 (21140) 21140..21418 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
NLZ06_RS23190 (21458) 21458..22306 + 849 WP_021265674.1 3'-5' exonuclease -
NLZ06_RS23195 (22423) 22423..22896 + 474 WP_001334658.1 hypothetical protein -
NLZ06_RS23200 (23373) 23373..23639 - 267 WP_000955263.1 hypothetical protein -
NLZ06_RS23205 (23639) 23639..24133 - 495 WP_001459505.1 hypothetical protein -
NLZ06_RS23210 (24189) 24189..24791 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid dfrA1 / blaTEM-1B / sul2 - 1..112664 112664


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T250844 WP_244442846.1 NZ_CP100546:21140-21418 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT250844 WP_000079941.1 NZ_CP100546:20871-21140 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References