45355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 55131..55395 Replicon plasmid PCN061p5
Accession NZ_CP006641
Organism Escherichia coli PCN061

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag PCN061_RS23815 Protein ID WP_001331364.1
Coordinates 55243..55395 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 55131..55188 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCN061_RS23800 50370..52661 - 2292 WP_001289276.1 hypothetical protein -
PCN061_RS23805 52654..53724 - 1071 WP_000151583.1 IncI1-type conjugal transfer protein TrbB -
PCN061_RS23810 53743..54951 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 55131..55188 - 58 NuclAT_0 - Antitoxin
- 55131..55188 - 58 NuclAT_0 - Antitoxin
- 55131..55188 - 58 NuclAT_0 - Antitoxin
- 55131..55188 - 58 NuclAT_0 - Antitoxin
PCN061_RS23815 55243..55395 + 153 WP_001331364.1 Hok/Gef family protein Toxin
PCN061_RS23820 55467..55718 - 252 WP_001291964.1 hypothetical protein -
PCN061_RS29525 56377..56553 - 177 WP_001054904.1 hypothetical protein -
PCN061_RS23840 56945..57154 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
PCN061_RS23845 57226..57876 - 651 WP_001178506.1 plasmid IncI1-type surface exclusion protein ExcA -
PCN061_RS23850 57950..60118 - 2169 WP_021265679.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid floR - 1..103644 103644


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T45355 WP_001331364.1 NZ_CP006641:55243-55395 [Escherichia coli PCN061]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T45355 NZ_CP006641:55243-55395 [Escherichia coli PCN061]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 58 bp

>AT45355 NZ_CP006641:c55188-55131 [Escherichia coli PCN061]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References