Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 101129..101676 Replicon plasmid pEC012-3
Accession NZ_CP119580
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag P1J04_RS25585 Protein ID WP_244442846.1
Coordinates 101398..101676 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag P1J04_RS25580 Protein ID WP_000079941.1
Coordinates 101129..101398 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS25555 (96773) 96773..97306 - 534 WP_001372168.1 transcription termination/antitermination NusG family protein -
P1J04_RS25560 (97748) 97748..98035 - 288 WP_000074849.1 conjugal transfer protein TraA -
P1J04_RS25565 (97953) 97953..98183 - 231 WP_228772074.1 ash family protein -
P1J04_RS25570 (99189) 99189..100220 + 1032 WP_000907870.1 plasmid replication initiator RepA -
P1J04_RS25575 (100916) 100916..101074 + 159 WP_000841008.1 hypothetical protein -
P1J04_RS25580 (101129) 101129..101398 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
P1J04_RS25585 (101398) 101398..101676 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
P1J04_RS25590 (101716) 101716..102564 + 849 WP_001057996.1 3'-5' exonuclease -
P1J04_RS25595 (102681) 102681..103154 + 474 WP_001334658.1 hypothetical protein -
P1J04_RS25600 (103634) 103634..103900 - 267 WP_000955263.1 hypothetical protein -
P1J04_RS25605 (103900) 103900..104085 - 186 Protein_120 hypothetical protein -
P1J04_RS25610 (104118) 104118..105632 - 1515 Protein_121 Tn3-like element TnAs1 family transposase -
P1J04_RS25615 (105698) 105698..106402 + 705 WP_276131593.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid fosA3 / blaCTX-M-123 - 1..106531 106531
- flank IS/Tn - - 105698..106402 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T274249 WP_244442846.1 NZ_CP119580:101398-101676 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT274249 WP_000079941.1 NZ_CP119580:101129-101398 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References