10179

Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) phd-doc/-
Location 1807207..1807832 Replicon chromosome
Accession NZ_LT571449
Organism Staphylococcus epidermidis isolate BPH0662

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag BN6763_RS09260 Protein ID WP_002504557.1
Coordinates 1807207..1807602 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag BN6763_RS09265 Protein ID WP_002504558.1
Coordinates 1807602..1807832 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN6763_RS09225 1802875..1803279 + 405 WP_002504535.1 YolD-like family protein -
BN6763_RS09230 1803527..1804168 - 642 WP_002504537.1 hypothetical protein -
BN6763_RS09235 1804274..1804996 - 723 WP_002504538.1 hypothetical protein -
BN6763_RS09240 1805105..1805905 - 801 WP_000686449.1 metallophosphoesterase -
BN6763_RS09245 1805909..1806403 - 495 WP_010959224.1 hypothetical protein -
BN6763_RS09250 1806460..1806729 - 270 WP_000755772.1 hypothetical protein -
BN6763_RS09255 1806713..1806904 - 192 WP_002504556.1 hypothetical protein -
BN6763_RS09260 1807207..1807602 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BN6763_RS09265 1807602..1807832 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
BN6763_RS09270 1807995..1808513 - 519 WP_002504559.1 metallophosphoesterase -
BN6763_RS09275 1808513..1809163 - 651 WP_002504560.1 hypothetical protein -
BN6763_RS09280 1809163..1809480 - 318 WP_002504561.1 hypothetical protein -
BN6763_RS09285 1809473..1810198 - 726 WP_002504562.1 metallophosphoesterase -
BN6763_RS09290 1810198..1810419 - 222 WP_002504563.1 hypothetical protein -
BN6763_RS14435 1810439..1810615 - 177 WP_002504564.1 hypothetical protein -
BN6763_RS09295 1810608..1811150 - 543 WP_002504565.1 hypothetical protein -
BN6763_RS09300 1811166..1811438 - 273 WP_002504566.1 hypothetical protein -
BN6763_RS09305 1811464..1811619 - 156 WP_002504567.1 transcriptional activator RinB -
BN6763_RS09310 1811616..1811900 - 285 WP_002504568.1 hypothetical protein -
BN6763_RS09315 1811916..1812101 - 186 WP_001187008.1 hypothetical protein -
BN6763_RS09320 1812086..1812265 - 180 WP_002504569.1 hypothetical protein -
BN6763_RS09325 1812281..1812763 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1774530..1906238 131708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T10179 WP_002504557.1 NZ_LT571449:c1807602-1807207 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T10179 NZ_LT571449:c1807602-1807207 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT10179 WP_002504558.1 NZ_LT571449:c1807832-1807602 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT10179 NZ_LT571449:c1807832-1807602 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References

(1) Sadeghi Kalani Behrooz et al. (2018) Study of MazEF, sam, and phd-doc putative toxin-antitoxin systems in Staphylococcus epidermidis. Acta Microbiologica Et Immunologica Hungarica 65(1):81-91. [PubMed:29471693] in_silico


in_silico in silico analysis literature