Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 535354..535979 Replicon chromosome
Accession NZ_CP073883
Organism Staphylococcus epidermidis strain B1287175

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV54_RS02765 Protein ID WP_002504557.1
Coordinates 535584..535979 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV54_RS02760 Protein ID WP_002504558.1
Coordinates 535354..535584 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV54_RS02695 (KFV54_02695) 530423..530905 + 483 WP_002504570.1 hypothetical protein -
KFV54_RS02700 (KFV54_02700) 530921..531100 + 180 WP_002504569.1 hypothetical protein -
KFV54_RS02705 (KFV54_02705) 531085..531270 + 186 WP_001187008.1 hypothetical protein -
KFV54_RS02710 (KFV54_02710) 531286..531570 + 285 WP_002504568.1 hypothetical protein -
KFV54_RS02715 (KFV54_02715) 531567..531722 + 156 WP_002504567.1 transcriptional activator RinB -
KFV54_RS02720 (KFV54_02720) 531748..532020 + 273 WP_002504566.1 hypothetical protein -
KFV54_RS02725 (KFV54_02725) 532036..532578 + 543 WP_002504565.1 hypothetical protein -
KFV54_RS02730 (KFV54_02730) 532571..532747 + 177 WP_002504564.1 hypothetical protein -
KFV54_RS02735 (KFV54_02735) 532767..532988 + 222 WP_002504563.1 hypothetical protein -
KFV54_RS02740 (KFV54_02740) 532988..533713 + 726 WP_010959229.1 metallophosphoesterase -
KFV54_RS02745 (KFV54_02745) 533706..534023 + 318 WP_002504561.1 hypothetical protein -
KFV54_RS02750 (KFV54_02750) 534023..534673 + 651 WP_002504560.1 hypothetical protein -
KFV54_RS02755 (KFV54_02755) 534673..535191 + 519 WP_002504559.1 metallophosphoesterase -
KFV54_RS02760 (KFV54_02760) 535354..535584 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV54_RS02765 (KFV54_02765) 535584..535979 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV54_RS02770 (KFV54_02770) 536282..536473 + 192 WP_002504556.1 hypothetical protein -
KFV54_RS02775 (KFV54_02775) 536457..536726 + 270 WP_000755772.1 hypothetical protein -
KFV54_RS02780 (KFV54_02780) 536783..537277 + 495 WP_010959224.1 hypothetical protein -
KFV54_RS02785 (KFV54_02785) 537281..538081 + 801 WP_000686449.1 metallophosphoesterase -
KFV54_RS02790 (KFV54_02790) 538190..538912 + 723 WP_002504538.1 hypothetical protein -
KFV54_RS02795 (KFV54_02795) 539018..539659 + 642 WP_002504537.1 hypothetical protein -
KFV54_RS13440 539690..539824 - 135 WP_002504536.1 hypothetical protein -
KFV54_RS02800 (KFV54_02800) 539907..540311 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 434607..567551 132944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200459 WP_002504557.1 NZ_CP073883:535584-535979 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200459 NZ_CP097881:3952842-3953099 [Escherichia coli str. K-12 substr. MG1655]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200459 WP_002504558.1 NZ_CP073883:535354-535584 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200459 NZ_CP097881:3953111-3953656 [Escherichia coli str. K-12 substr. MG1655]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References