Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1716189..1716814 Replicon chromosome
Accession NZ_CP013943
Organism Staphylococcus epidermidis strain DAR1907

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag SE1UMMC_RS08750 Protein ID WP_002504557.1
Coordinates 1716189..1716584 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag SE1UMMC_RS08755 Protein ID WP_002504558.1
Coordinates 1716584..1716814 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SE1UMMC_RS08715 1711857..1712261 + 405 WP_002504535.1 YolD-like family protein -
SE1UMMC_RS08720 1712509..1713150 - 642 WP_002504537.1 hypothetical protein -
SE1UMMC_RS08725 1713256..1713978 - 723 WP_002504538.1 hypothetical protein -
SE1UMMC_RS08730 1714087..1714887 - 801 WP_000686449.1 metallophosphoesterase -
SE1UMMC_RS08735 1714891..1715385 - 495 WP_010959224.1 hypothetical protein -
SE1UMMC_RS08740 1715442..1715711 - 270 WP_000755772.1 hypothetical protein -
SE1UMMC_RS08745 1715695..1715886 - 192 WP_002504556.1 hypothetical protein -
SE1UMMC_RS08750 1716189..1716584 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SE1UMMC_RS08755 1716584..1716814 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
SE1UMMC_RS08760 1716977..1717495 - 519 WP_002504559.1 metallophosphoesterase -
SE1UMMC_RS08765 1717495..1718145 - 651 WP_002504560.1 hypothetical protein -
SE1UMMC_RS08770 1718145..1718462 - 318 WP_002504561.1 hypothetical protein -
SE1UMMC_RS08775 1718455..1719180 - 726 WP_002504562.1 metallophosphoesterase -
SE1UMMC_RS08780 1719180..1719401 - 222 WP_002504563.1 hypothetical protein -
SE1UMMC_RS13955 1719421..1719597 - 177 WP_002504564.1 hypothetical protein -
SE1UMMC_RS08785 1719590..1720132 - 543 WP_101750554.1 hypothetical protein -
SE1UMMC_RS08790 1720148..1720420 - 273 WP_002504566.1 hypothetical protein -
SE1UMMC_RS08795 1720446..1720601 - 156 WP_002504567.1 transcriptional activator RinB -
SE1UMMC_RS08800 1720598..1720882 - 285 WP_002504568.1 hypothetical protein -
SE1UMMC_RS08805 1720898..1721083 - 186 WP_001187008.1 hypothetical protein -
SE1UMMC_RS08810 1721068..1721247 - 180 WP_002504569.1 hypothetical protein -
SE1UMMC_RS08815 1721263..1721745 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') groEL 1656975..1812337 155362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T59632 WP_002504557.1 NZ_CP013943:c1716584-1716189 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T59632 NZ_CP013943:c1716584-1716189 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT59632 WP_002504558.1 NZ_CP013943:c1716814-1716584 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT59632 NZ_CP013943:c1716814-1716584 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References